Seizures as the main presenting manifestation of acute SARS-CoV-2 infection in children.
COVID-19
SARS-CoV-2
Seizures
Status epilepticus
Journal
Seizure
ISSN: 1532-2688
Titre abrégé: Seizure
Pays: England
ID NLM: 9306979
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
30
05
2021
revised:
26
07
2021
accepted:
25
08
2021
pubmed:
5
9
2021
medline:
17
11
2021
entrez:
4
9
2021
Statut:
ppublish
Résumé
To explore the rate, characteristics, risk factors, and prognosis of children presenting with seizures as the main symptom of acute COVID-19 (coronavirus disease 2019). We conducted a systematic retrospective study to identify all children who presented to the emergency departments of a tertiary academic medical center between March 1st and December 31st 2020 and had a SARS-CoV-2 infection based on RT-PCR (reverse transcription-polymerase chain reaction) from nasopharyngeal swab. Clinical and demographic data were extracted from the electronic medical records and reviewed. Total of 175 children were diagnosed with acute SARS-CoV-2 infection in the emergency departments during the study period. Of those, 11 presented with seizures. Age ranged from six months to 17 years and 4 were girls. Five presented with status epilepticus and responded to loading doses of anti-seizure medications. Six had fever. Seven had prior history of neurological disorder. Full recovery was the rule. Unlike in adults, seizures occur early and may be the main manifestation of acute COVID-19 in children. Seizures, including status epilepticus, may occur without fever even in children with no history of epilepsy and are not associated with severe disease. A high index of suspicion is required for early diagnosis thus infection control measures can be taken.
Identifiants
pubmed: 34481322
pii: S1059-1311(21)00295-8
doi: 10.1016/j.seizure.2021.08.017
pmc: PMC8397499
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-93Informations de copyright
Copyright © 2021. Published by Elsevier Ltd.
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