Discovery and delivery strategies for engineered live biotherapeutic products.
drug delivery
drug discovery
gastrointestinal physiology
live biotherapeutic products
multi-omics
Journal
Trends in biotechnology
ISSN: 1879-3096
Titre abrégé: Trends Biotechnol
Pays: England
ID NLM: 8310903
Informations de publication
Date de publication:
03 2022
03 2022
Historique:
received:
18
05
2021
revised:
02
08
2021
accepted:
03
08
2021
pubmed:
6
9
2021
medline:
24
3
2022
entrez:
5
9
2021
Statut:
ppublish
Résumé
Genetically engineered microbes that secrete therapeutics, sense and respond to external environments, and/or target specific sites in the gut fall under an emergent class of therapeutics, called live biotherapeutic products (LBPs). As live organisms that require symbiotic host interactions, LBPs offer unique therapeutic opportunities, but also face distinct challenges in the gut microenvironment. In this review, we describe recent approaches (often demonstrated using traditional probiotic microorganisms) to discover LBP chassis and genetic parts utilizing omics-based methods and highlight LBP delivery strategies, with a focus on addressing physiological challenges that LBPs encounter after oral administration. Finally, we share our perspective on the opportunity to apply an integrated approach, wherein discovery and delivery strategies are utilized synergistically, towards tailoring and optimizing LBP efficacy.
Identifiants
pubmed: 34481657
pii: S0167-7799(21)00176-1
doi: 10.1016/j.tibtech.2021.08.002
pmc: PMC8831446
mid: NIHMS1732376
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
354-369Subventions
Organisme : NIGMS NIH HHS
ID : R35 GM137898
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests No interests are declared.
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