Terpenoid treatment in osteoporosis: this is where we have come in research.
bone erosive diseases
osteoblast
osteoclast
osteoporosis
terpenoids
Journal
Trends in endocrinology and metabolism: TEM
ISSN: 1879-3061
Titre abrégé: Trends Endocrinol Metab
Pays: United States
ID NLM: 9001516
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
14
05
2021
revised:
26
07
2021
accepted:
30
07
2021
pubmed:
6
9
2021
medline:
28
4
2022
entrez:
5
9
2021
Statut:
ppublish
Résumé
Lower bone resistance to load is due to the imbalance of bone homeostasis, where excessive bone resorption, compared with bone formation, determines a progressive osteopenia, leading to a high risk of fractures and consequent pain and functional limitations. Terpenoids, with their activities against bone resorption, have recently received increased attention from researchers. They are potentially more suitable for long-term use compared with traditional therapeutics. In this review of the literature of the past 5 years, we provide comprehensive information on terpenoids, with their anti-osteoporotic effects, highlighting molecular mechanisms that are often in epigenetic key and a possible pharmacological use in osteoporosis prevention and treatment.
Identifiants
pubmed: 34481733
pii: S1043-2760(21)00180-6
doi: 10.1016/j.tem.2021.07.011
pii:
doi:
Substances chimiques
Terpenes
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
846-861Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.