Antimicrobial peptidomes of Bothrops atrox and Bothrops jararacussu snake venoms.

Animals Anti-Bacterial Agents / chemistry Anti-Infective Agents / chemistry Antimalarials / chemistry Bothrops Crotalid Venoms / chemistry Hemolytic Agents / chemistry Humans Leishmania / drug effects Microbial Sensitivity Tests Peptides / chemistry Plasmodium falciparum / drug effects Pseudomonas aeruginosa / drug effects Spectrometry, Mass, Electrospray Ionization Staphylococcus aureus / drug effects
Antimicrobial peptide Bothrops atrox Bothrops jararacussu Peptidomics Snake venom peptidome

Journal

Amino acids
ISSN: 1438-2199
Titre abrégé: Amino Acids
Pays: Austria
ID NLM: 9200312

Informations de publication

Date de publication:
Oct 2021
Historique:
received: 06 08 2020
accepted: 11 07 2021
pubmed: 6 9 2021
medline: 5 2 2022
entrez: 5 9 2021
Statut: ppublish

Résumé

The worrisome emergence of pathogens resistant to conventional drugs has stimulated the search for new classes of antimicrobial and antiparasitic agents from natural sources. Antimicrobial peptides (AMPs), acting through mechanisms that do not rely on the interaction with a specific receptor, provide new possibilities for the development of drugs against resistant organisms. This study sought to purify and proteomically characterize the antimicrobial and antiparasitic peptidomes of B. atrox and B. jararacussu snake venoms against Gram-positive (Staphylococcus aureus, Methicillin-resistant Staphylococcus aureus-MRSA), Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae) bacteria, and the protozoan parasites Leishmania amazonensis and Plasmodium falciparum (clone W2, resistant to chloroquine). To this end, B. atrox and B. jararacussu venom peptides were purified by combination of 3 kDa cut-off Amicon

Identifiants

DOI: 10.1007/s00726-021-03055-y PMID: 34482475
pubmed: 34482475
doi: 10.1007/s00726-021-03055-y
pii: 10.1007/s00726-021-03055-y
doi:

Substances chimiques

Anti-Bacterial Agents 0
Anti-Infective Agents 0
Antimalarials 0
Crotalid Venoms 0
Hemolytic Agents 0
Peptides 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1635-1648

Subventions

Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : # 406385/2018
Organisme : Conselho Nacional de Desenvolvimento Científico e Tecnológico
ID : 303792/2016-1
Organisme : Universidad de Buenos Aires
ID : # 01.12.0450.0
Organisme : Financiadora de Estudos e Projetos
ID : 01.09.0278.04

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.

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Auteurs

Cleópatra Alves da Silva Caldeira (CA)

Center for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil. cleopatra@unir.br.
Graduate Program in Biodiversity and Biotechnology, BIONORTE Network, Porto Velho, RO, Brazil. cleopatra@unir.br.
Graduate Program in Experimental Biology (PGBIOEXP), Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil. cleopatra@unir.br.
ORCID: 0000-0003-1670-5227

Rafaela Diniz-Sousa (R)

Center for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil.
Graduate Program in Experimental Biology (PGBIOEXP), Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil.
São Lucas University Center (UniSL), Porto Velho, RO, Brazil.

Daniel Carvalho Pimenta (DC)

Biochemistry and Biophysics Laboratory, Butantan Institute, Sao Paulo, SP, Brazil.

Ana Paula Azevedo Dos Santos (APA)

Graduate Program in Experimental Biology (PGBIOEXP), Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil.
Malaria and Leishmaniasis Bioassay Platform, PBML, Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil.

Carolina Bioni Garcia Teles (CBG)

Graduate Program in Biodiversity and Biotechnology, BIONORTE Network, Porto Velho, RO, Brazil.
Graduate Program in Experimental Biology (PGBIOEXP), Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil.
São Lucas University Center (UniSL), Porto Velho, RO, Brazil.
Malaria and Leishmaniasis Bioassay Platform, PBML, Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil.

Najla Benevides Matos (NB)

Microbiology Laboratory, Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Research Center on Tropical Medicine of Rondônia (CEPEM), Porto Velho, RO, Brazil.

Saulo Luís da Silva (SL)

College of Biochemistry and Pharmacy, Faculty of Chemical Sciences, University of Cuenca, Cuenca, Azuay, Ecuador.
Chemistry and Biochemistry Department, Faculty of Sciences, University of Porto, Porto, Portugal.
LAQV - REQUIMTE, University of Porto, Porto, Portugal.

Rodrigo Guerino Stabeli (RG)

Translational Medicine Platform, Fiocruz, Ribeirão Preto, São Paulo, Brazil.
Faculty of Medicine of the Federal University of São Carlos (UFSCAR), São Paulo, Brazil.

Silvia Andrea Camperi (SA)

Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Biotecnología, Buenos Aires, Argentina.
CONICET-Universidad de Buenos Aires, Instituto de Nanobiotecnología (NANOBIOTEC), Facultad de Farmacia y Bioquímica, Buenos Aires, Argentina.

Andreimar Martins Soares (AM)

Center for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil.
Graduate Program in Biodiversity and Biotechnology, BIONORTE Network, Porto Velho, RO, Brazil.
Graduate Program in Experimental Biology (PGBIOEXP), Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil.
São Lucas University Center (UniSL), Porto Velho, RO, Brazil.

Leonardo de Azevedo Calderon (L)

Center for the Study of Biomolecules Applied to Health (CEBio), Oswaldo Cruz Foundation Rondônia, FIOCRUZ, Porto Velho, RO, Brazil. calderon@unir.br.
Graduate Program in Biodiversity and Biotechnology, BIONORTE Network, Porto Velho, RO, Brazil. calderon@unir.br.
Graduate Program in Experimental Biology (PGBIOEXP), Federal University of Rondônia (UNIR), Porto Velho, RO, Brazil. calderon@unir.br.
Aparício Carvalho University Center (FIMCA), Porto Velho, RO, Brazil. calderon@unir.br.

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Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
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Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antibactériens › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Antipaludiques › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Reptiles › Serpents › Alethinophidia › Viperidae › Crotalinae › Bothrops › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Venins › Venins de serpent › Venins de vipère › Venins de crotalidé › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Noxas › Cytotoxines › Hémolytiques › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Leishmania › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Tests de sensibilité microbienne › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Eucaryotes › Alveolata › Apicomplexa › Haemosporida › Plasmodium › Plasmodium falciparum › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Pseudomonadaceae › Pseudomonas › Pseudomonas aeruginosa › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse ESI › Antimicrobial peptidomes of Bothrops atrox and...
questionsmedicales.fr › Bactéries › Bactéries à Gram positif › Cocci à Gram positif › Staphylococcaceae › Staphylococcus › Staphylococcus aureus › Antimicrobial peptidomes of Bothrops atrox and...