Mitofusin 2, a key coordinator between mitochondrial dynamics and innate immunity.
Mitofusin-2
infections
innate immunity
mitochondrial dynamics
Journal
Virulence
ISSN: 2150-5608
Titre abrégé: Virulence
Pays: United States
ID NLM: 101531386
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
27
1
2022
Statut:
ppublish
Résumé
Remodeling of mitochondrial dynamics and mitochondrial morphology plays a pivotal role in the maintenance of mitochondrial homeostasis in response to pathogenic attacks or stress stimuli. In addition to their role in metabolism and energy production, mitochondria participate in diverse biological functions, including innate immune responses driven by macrophages in response to infections or inflammatory stimuli. Mitofusin-2 (MFN2), a mitochondria-shaping protein regulating mitochondrial fusion and fission, plays a crucial role in linking mitochondrial function and innate immune responses. In this article, we review the role of MFN2 in the regulation of innate immune responses during viral and bacterial infections. We also summarize the current knowledge on the role of MFN2 in coordinating inflammatory, atherogenic, and fibrotic responses. MFN2-mediated crosstalk between mitochondrial dynamics and innate immune responses may determine the outcomes of pathogenic infections.
Identifiants
pubmed: 34482801
doi: 10.1080/21505594.2021.1965829
pmc: PMC8425681
doi:
Substances chimiques
Mitochondrial Proteins
0
Hydrolases
EC 3.-
GTP Phosphohydrolases
EC 3.6.1.-
MFN2 protein, human
EC 3.6.1.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
2273-2284Références
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