Mosquito transgenesis for malaria control.

Animals Anopheles / physiology Gene Transfer Techniques Malaria / parasitology Mosquito Control Mosquito Vectors / genetics
Anopheles Plasmodium antiparasitic effectors gene drive host factors mosquito transgenesis vector control

Journal

Trends in parasitology
ISSN: 1471-5007
Titre abrégé: Trends Parasitol
Pays: England
ID NLM: 100966034

Informations de publication

Date de publication:
01 2022
Historique:
received: 08 06 2021
revised: 01 08 2021
accepted: 03 08 2021
pubmed: 7 9 2021
medline: 9 4 2022
entrez: 6 9 2021
Statut: ppublish

Résumé

Malaria is one of the deadliest diseases. Because of the ineffectiveness of current malaria-control methods, several novel mosquito vector-based control strategies have been proposed to supplement existing control strategies. Mosquito transgenesis and gene drive have emerged as promising tools for preventing the spread of malaria by either suppressing mosquito populations by self-destructing mosquitoes or replacing mosquito populations with disease-refractory populations. Here we review the development of mosquito transgenesis and its application for malaria control, highlighting the transgenic expression of antiparasitic effector genes, inactivation of host factor genes, and manipulation of miRNAs and lncRNAs. Overall, from a malaria-control perspective, mosquito transgenesis is not envisioned as a stand-alone approach; rather, its use is proposed as a complement to existing vector-control strategies.

Identifiants

DOI: 10.1016/j.pt.2021.08.001 PMID: 34483052
pubmed: 34483052
pii: S1471-4922(21)00199-9
doi: 10.1016/j.pt.2021.08.001
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

54-66

Subventions

Organisme : NIAID NIH HHS
ID : R01 AI122743
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI131574
Pays : United States

Informations de copyright

Copyright © 2021 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests There are no interests to declare.

Auteurs

Shengzhang Dong (S)

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Yuemei Dong (Y)

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

Maria L Simões (ML)

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA.

George Dimopoulos (G)

W. Harry Feinstone Department of Molecular Microbiology and Immunology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA. Electronic address: gdimopo1@jhu.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Mosquito transgenesis for malaria control.
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Nematocera › Culicomorpha › Culicidae › Anopheles › Mosquito transgenesis for malaria control.
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Techniques de transfert de gènes › Mosquito transgenesis for malaria control.
questionsmedicales.fr › Infection › Maladies vectorielles › Paludisme › Mosquito transgenesis for malaria control.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pratiques en santé publique › Contrôle des maladies transmissibles › Lutte contre les nuisibles › Lutte contre les insectes › Lutte contre les moustiques › Mosquito transgenesis for malaria control.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Chaîne d'infection › Vecteurs de maladies › Vecteurs arthropodes › Vecteurs insectes › Vecteurs moustiques › Mosquito transgenesis for malaria control.