Trajectories of alcohol consumption during life and the risk of developing breast cancer.
Journal
British journal of cancer
ISSN: 1532-1827
Titre abrégé: Br J Cancer
Pays: England
ID NLM: 0370635
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
09
03
2021
accepted:
08
07
2021
revised:
10
06
2021
pubmed:
7
9
2021
medline:
18
12
2021
entrez:
6
9
2021
Statut:
ppublish
Résumé
Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood. The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.
Sections du résumé
BACKGROUND
Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive.
OBJECTIVE
To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC).
METHODS
1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime.
RESULTS
Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption (<5 g/day) throughout their life. The second included those (33%) who gradually moved from a low alcohol consumption in adolescence to a moderate in adulthood (5 to <15 g/day), never having a high consumption; and oppositely, women in the third trajectory (16%) moved from moderate consumption in adolescence, to a lower consumption in adulthood. Women in the fourth (6%) moved from a moderate alcohol consumption in adolescence to the highest consumption in adulthood (≥15 g/day), never having a low alcohol consumption. Comparing with the first trajectory, the fourth doubled BC risk (OR 2.19; 95% CI 1.27, 3.77), followed by the third (OR 1.44; 0.96, 2.16) and ultimately by the second trajectory (OR 1.17; 0.86, 1.58). The magnitude of BC risk was greater in postmenopausal women, especially in those with underweight or normal weight. When alcohol consumption was independently examined at each life stage, ≥15 g/day of alcohol consumption in adolescence was strongly associated with BC risk followed by consumption in adulthood.
CONCLUSIONS
The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk.
Identifiants
pubmed: 34483338
doi: 10.1038/s41416-021-01492-w
pii: 10.1038/s41416-021-01492-w
pmc: PMC8505448
doi:
Types de publication
Comparative Study
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1168-1176Informations de copyright
© 2021. The Author(s).
Références
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68:394–424.
pubmed: 30207593
doi: 10.3322/caac.21492
Colditz GA, Rosner B. Cumulative risk of breast cancer to age 70 years according to risk factor status: data from the Nurses’ Health Study. Am J Epidemiol. 2000;152:950–64.
pubmed: 11092437
doi: 10.1093/aje/152.10.950
World Cancer Research Fund, American Institute for Cancer Research. Food, nutrition, physical activity, and the prevention of cancer: a global perspective. Amer Inst for Cancer Research; 2007.
IARC Working Group on the Evaluation of Carcinogenic Risks to Humans. Alcohol consumption and ethyl carbamate. IARC Monogr Eval Carcinog Risks Hum. 2010;96:3–1383.
pmcid: 4781168
World Cancer Research Fund. Alcoholic drinks and the risk of cancer. 2018. https://www.wcrf.org/wp-content/uploads/2021/02/Alcoholic-Drinks.pdf .
Russo J, Hu YF, Silva ID, Russo IH. Cancer risk related to mammary gland structure and development. Microsc Res Tech. 2001;52:204–23.
pubmed: 11169868
doi: 10.1002/1097-0029(20010115)52:2<204::AID-JEMT1006>3.0.CO;2-F
Russo J, Russo IH. Differentiation and breast cancer. Medicina (B Aires). 1997;57:81–91.
pubmed: 9567346
Russo IH, Russo J. Pregnancy-induced changes in breast cancer risk. J. Mammary Gland Biol. Neoplasia. 2011;16:221–33.
pubmed: 21805333
doi: 10.1007/s10911-011-9228-y
Colditz GA, Frazier AL. Models of breast cancer show that risk is set by events of early life: prevention efforts must shift focus. Cancer Epidemiol Biomark Prev. 1995;4:567–71.
Anderson LN, Cotterchio M, Boucher BA, Kreiger N. Phytoestrogen intake from foods, during adolescence and adulthood, and risk of breast cancer by estrogen and progesterone receptor tumor subgroup among Ontario women. Int J Cancer 2013;132:1683–92.
pubmed: 22907507
doi: 10.1002/ijc.27788
Land CE, Tokunaga M, Koyama K, Soda M, Preston DL, Nishimori I, et al. Incidence of female breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-1990. Radiat Res. 2003;160:707–17.
pubmed: 14640793
doi: 10.1667/RR3082
Liu Y, Nguyen N, Colditz GA. Links between alcohol consumption and breast cancer: a look at the evidence. Women’s Health (Lond.). 2015;11:65–77.
pmcid: 4299758
doi: 10.2217/WHE.14.62
Jones BL, Nagin DS, Roeder K. A SAS procedure based on mixture models for estimating developmental trajectories. Sociol Methods Res. 2001;29:374–93.
doi: 10.1177/0049124101029003005
Jones BL, Nagin DS. Advances in group-based trajectory modeling and an SAS procedure for estimating them. Sociol Methods Res. 2007;35:542–71.
doi: 10.1177/0049124106292364
Goldhirsch A, Winer EP, Coates AS, Gelber RD, Piccart-Gebhart M, Thurlimann B, et al. Personalizing the treatment of women with early breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2013. Ann. Oncol. 2013;24:2206–23.
pubmed: 23917950
pmcid: 3755334
doi: 10.1093/annonc/mdt303
Wolff AC, Hammond MEH, Allison KH, Harvey BE, Mangu PB, Bartlett JMS, et al. Human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Focused Update. J Clin Oncol. 2018;36:2105–22.
pubmed: 29846122
doi: 10.1200/JCO.2018.77.8738
Hammond ME, Hayes DF, Wolff AC, Mangu PB, Temin S. American society of clinical oncology/college of american pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer. J Oncol Pract. 2010;6:195–7.
pubmed: 21037871
pmcid: 2900870
doi: 10.1200/JOP.777003
Chasan-Taber L, Erickson JB, Nasca PC, Chasan-Taber S, Freedson PS. Validity and reproducibility of a physical activity questionnaire in women. Med Sci Sports Exerc. 2002;34:987–92.
pubmed: 12048326
doi: 10.1097/00005768-200206000-00013
Lope V, Martin M, Castello A, Casla S, Ruiz A, Baena-Canada JM, et al. Physical activity and breast cancer risk by pathological subtype. Gynecol Oncol. 2017;144:577–85.
pubmed: 28057355
doi: 10.1016/j.ygyno.2016.12.014
Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, et al. Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol. 1985;122:51–65.
pubmed: 4014201
doi: 10.1093/oxfordjournals.aje.a114086
Vioque J, Navarrete-Munoz EM, Gimenez-Monzo D, Garcia-de-la-Hera M, Granado F, Young IS, et al. Reproducibility and validity of a food frequency questionnaire among pregnant women in a Mediterranean area. Nutr J. 2013;12:26.
pubmed: 23421854
pmcid: 3584829
doi: 10.1186/1475-2891-12-26
Martin-Moreno JM, Boyle P, Gorgojo L, Maisonneuve P, Fernandez-Rodriguez JC, Salvini S, et al. Development and validation of a food frequency questionnaire in Spain. Int J Epidemiol. 1993;22:512–9.
pubmed: 8359969
doi: 10.1093/ije/22.3.512
Castello A, Pollan M, Buijsse B, Ruiz A, Casas AM, Baena-Canada JM, et al. Spanish Mediterranean diet and other dietary patterns and breast cancer risk: case-control EpiGEICAM study. Br J Cancer 2014;111:1454–62.
pubmed: 25101568
pmcid: 4183855
doi: 10.1038/bjc.2014.434
DiLoreto JT, Siegel M, Hinchey D, Valerio H, Kinzel K, Lee S, et al. Assessment of the average price and ethanol content of alcoholic beverages by brand-United States, 2011. Alcohol Clin Exp Res. 2012;36:1288–97.
pubmed: 22316218
pmcid: 3349795
doi: 10.1111/j.1530-0277.2011.01721.x
Cao Y, Willett WC, Rimm EB, Stampfer MJ, Giovannucci EL. Light to moderate intake of alcohol, drinking patterns, and risk of cancer: results from two prospective US cohort studies. BMJ 2015;351:h4238.
pubmed: 26286216
pmcid: 4540790
doi: 10.1136/bmj.h4238
Allen NE, Beral V, Casabonne D, Kan SW, Reeves GK, Brown A, et al. Moderate alcohol intake and cancer incidence in women. J Natl Cancer Inst. 2009;101:296–305.
pubmed: 19244173
doi: 10.1093/jnci/djn514
Jones BL, Nagin DS. A note on a Stata plugin for estimating group-based trajectory models. Sociol Methods Res. 2013;42:608–13.
doi: 10.1177/0049124113503141
Nagin DS. Group-Based Modeling of Development. Cambridge, MA: Harvard University Press; 2005.
Nagin DS. Group-based trajectory modeling: an overview. Ann Nutr Metab. 2014;65:205–10.
pubmed: 25413659
doi: 10.1159/000360229
White IR, Royston P, Wood AM. Multiple imputation using chained equations: Issues and guidance for practice. Stat Med. 2011;30:377–99.
pubmed: 21225900
doi: 10.1002/sim.4067
Lee KJ, Carlin JB. Multiple imputation for missing data: fully conditional specification versus multivariate normal imputation. Am J Epidemiol. 2010;171:624–32.
pubmed: 20106935
doi: 10.1093/aje/kwp425
Chen WY, Rosner B, Hankinson SE, Colditz GA, Willett WC. Moderate alcohol consumption during adult life, drinking patterns, and breast cancer risk. JAMA 2011;306:1884–90.
pubmed: 22045766
pmcid: 3292347
doi: 10.1001/jama.2011.1590
Liu Y, Colditz GA, Rosner B, Berkey CS, Collins LC, Schnitt SJ, et al. Alcohol intake between menarche and first pregnancy: a prospective study of breast cancer risk. J Natl Cancer Inst. 2013;105:1571–8.
pubmed: 23985142
pmcid: 3797023
doi: 10.1093/jnci/djt213
Romieu I, Scoccianti C, Chajes V, de Batlle J, Biessy C, Dossus L, et al. Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition. Int J Cancer. 2015;137:1921–30.
pubmed: 25677034
pmcid: 6300114
doi: 10.1002/ijc.29469
Terry MB, Zhang FF, Kabat G, Britton JA, Teitelbaum SL, Neugut AI, et al. Lifetime alcohol intake and breast cancer risk. Ann Epidemiol. 2006;16:230–40.
pubmed: 16230024
doi: 10.1016/j.annepidem.2005.06.048
Young TB. A case-control study of breast cancer and alcohol consumption habits. Cancer 1989;64:552–8.
pubmed: 2736501
doi: 10.1002/1097-0142(19890715)64:2<552::AID-CNCR2820640233>3.0.CO;2-Y
Harvey EB, Schairer C, Brinton LA, Hoover RN, Fraumeni JF Jr. Alcohol consumption and breast cancer. J Natl Cancer Inst. 1987;78:657–61.
pubmed: 3104648
van’t Veer P, Kok FJ, Hermus RJ, Sturmans F. Alcohol dose, frequency and age at first exposure in relation to the risk of breast cancer. Int J Epidemiol. 1989;18:511–7.
pubmed: 2807651
doi: 10.1093/ije/18.3.511
Berstad P, Ma H, Bernstein L, Ursin G. Alcohol intake and breast cancer risk among young women. Breast Cancer Res Treat. 2008;108:113–20.
pubmed: 17468952
doi: 10.1007/s10549-007-9578-8
Holmberg L, Baron JA, Byers T, Wolk A, Ohlander EM, Zack M, et al. Alcohol intake and breast cancer risk: effect of exposure from 15 years of age. Cancer Epidemiol Biomark Prev. 1995;4:843–7.
Longnecker MP, Newcomb PA, Mittendorf R, Greenberg ER, Clapp RW, Bogdan GF, et al. Risk of breast cancer in relation to lifetime alcohol consumption. J Natl Cancer Inst. 1995;87:923–9.
pubmed: 7666482
doi: 10.1093/jnci/87.12.923
Russo IH, Russo J. Role of hormones in mammary cancer initiation and progression. J Mammary Gland Biol Neoplasia. 1998;3:49–61.
pubmed: 10819504
doi: 10.1023/A:1018770218022
Fernandez SV, Russo J. Estrogen and xenoestrogens in breast cancer. Toxicol Pathol. 2010;38:110–22.
pubmed: 19933552
doi: 10.1177/0192623309354108
Nandi S, Guzman RC, Yang J. Hormones and mammary carcinogenesis in mice, rats, and humans: a unifying hypothesis. Proc Natl Acad Sci USA. 1995;92:3650–7.
pubmed: 7731959
pmcid: 42019
doi: 10.1073/pnas.92.9.3650
Hartman TJ, Sisti JS, Hankinson SE, Xu X, Eliassen AH, Ziegler R. Alcohol consumption and urinary estrogens and estrogen metabolites in premenopausal women. Horm Cancer. 2016;7:65–74.
pubmed: 26728472
pmcid: 4729640
doi: 10.1007/s12672-015-0249-7
Katsouyanni K, Boyle P, Trichopoulos D. Diet and urine estrogens among postmenopausal women. Oncology. 1991;48:490–4.
pubmed: 1749588
doi: 10.1159/000226987
Endogenous H, Breast Cancer Collaborative G, Key TJ, Appleby PN, Reeves GK, Roddam AW, et al. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies. Br J Cancer. 2011;105:709–22.
doi: 10.1038/bjc.2011.254
Frydenberg H, Flote VG, Larsson IM, Barrett ES, Furberg AS, Ursin G, et al. Alcohol consumption, endogenous estrogen and mammographic density among premenopausal women. Breast Cancer Res. 2015;17:103.
pubmed: 26246001
pmcid: 4531831
doi: 10.1186/s13058-015-0620-1
Mahabir S, Baer DJ, Johnson LL, Dorgan JF, Campbell W, Brown E, et al. The effects of moderate alcohol supplementation on estrone sulfate and DHEAS in postmenopausal women in a controlled feeding study. Nutr J. 2004;3:11.
pubmed: 15353002
pmcid: 517945
doi: 10.1186/1475-2891-3-11
Ginsburg ES, Walsh BW, Shea BF, Gao X, Gleason RE, Barbieri RL. The effects of ethanol on the clearance of estradiol in postmenopausal women. Fertil Steril. 1995;63:1227–30.
pubmed: 7750592
doi: 10.1016/S0015-0282(16)57602-X
Gill J. The effects of moderate alcohol consumption on female hormone levels and reproductive function. Alcohol Alcohol. 2000;35:417–23.
pubmed: 11022013
doi: 10.1093/alcalc/35.5.417
Tan DJ, Barber JS, Shields PG. Alcohol drinking and breast cancer. Breast Cancer Online. 2006;9:1.
doi: 10.1017/S1470903106003105
Garro AJ, Lieber CS. Alcohol and cancer. Annu Rev Pharm Toxicol. 1990;30:219–49.
doi: 10.1146/annurev.pa.30.040190.001251
Gandini S, Merzenich H, Robertson C, Boyle P. Meta-analysis of studies on breast cancer risk and diet: the role of fruit and vegetable consumption and the intake of associated micronutrients. Eur J Cancer. 2000;36:636–46.
pubmed: 10738129
doi: 10.1016/S0959-8049(00)00022-8
Chollet-Hinton L, Anders CK, Tse CK, Bell MB, Yang YC, Carey LA, et al. Breast cancer biologic and etiologic heterogeneity by young age and menopausal status in the Carolina Breast Cancer Study: a case-control study. Breast Cancer Res. 2016;18:79.
pubmed: 27492244
pmcid: 4972943
doi: 10.1186/s13058-016-0736-y
Claus EB, Schildkraut JM, Thompson WD, Risch NJ. The genetic attributable risk of breast and ovarian cancer. Cancer 1996;77:2318–24.
pubmed: 8635102
doi: 10.1002/(SICI)1097-0142(19960601)77:11<2318::AID-CNCR21>3.0.CO;2-Z
Endogenous Hormones Breast Cancer Collaborative Group. Body mass index, serum sex hormones, and breast cancer risk in postmenopausal women. J Natl Cancer Inst. 2003;95:1218–26.
doi: 10.1093/jnci/djg022
Verkasalo PK, Thomas HV, Appleby PN, Davey GK, Key TJ. Circulating levels of sex hormones and their relation to risk factors for breast cancer: a cross-sectional study in 1092 pre- and postmenopausal women (United Kingdom). Cancer Causes Control. 2001;12:47–59.
pubmed: 11227925
doi: 10.1023/A:1008929714862
Hirko KA, Chen WY, Willett WC, Rosner BA, Hankinson SE, Beck AH, et al. Alcohol consumption and risk of breast cancer by molecular subtype: Prospective analysis of the nurses’ health study after 26 years of follow-up. Int J. Cancer. 2016;138:1094–101.
pubmed: 26384849
doi: 10.1002/ijc.29861
Longnecker MP, Newcomb PA, Mittendorf R, Greenberg ER, Clapp RW, Bogdan G, et al. The reliability of self-reported alcohol consumption in the remote past. Epidemiology. 1992;3:535–9.
pubmed: 1420522
doi: 10.1097/00001648-199211000-00014
Thibaut F. Alert out on tobacco and alcohol consumption in young European women. Eur Arch Psychiatry Clin Neurosci. 2018;268:317–9.
pubmed: 29737407
doi: 10.1007/s00406-018-0901-7
Kraus L, Nociar A. ESPAD report 2015: results from the European school survey project on alcohol and other drugs: European Monitoring Centre for Drugs and Drug Addiction; 2016.
Ministerio de Sanidad, Consumo y Bienestar Social. In Ministerio de Sanidad (Ed.), ESTUDES 2018/2019. Encuesta sobre uso de drogas en enseñanzas secundarias en España. 1994-2018/2019 (1ª ed.), Madrid; 2020. https://pnsd.sanidad.gob.es/profesionales/sistemasInformacion/sistemaInformacion/pdf/ESTUDES_2018-19_Presentacion.pdf .