Collagen- and hyaluronic acid-based hydrogels and their biomedical applications.
Fabrication
Microstructure
dynamic properties
extracellular matrix
semi-interpenetrating network
Journal
Materials science & engineering. R, Reports : a review journal
ISSN: 0927-796X
Titre abrégé: Mater Sci Eng R Rep
Pays: Switzerland
ID NLM: 101322263
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
Hydrogels have been widely investigated in biomedical fields due to their similar physical and biochemical properties to the extracellular matrix (ECM). Collagen and hyaluronic acid (HA) are the main components of the ECM in many tissues. As a result, hydrogels prepared from collagen and HA hold inherent advantages in mimicking the structure and function of the native ECM. Numerous studies have focused on the development of collagen and HA hydrogels and their biomedical applications. In this extensive review, we provide a summary and analysis of the sources, features, and modifications of collagen and HA. Specifically, we highlight the fabrication, properties, and potential biomedical applications as well as promising commercialization of hydrogels based on these two natural polymers.
Identifiants
pubmed: 34483486
doi: 10.1016/j.mser.2021.100641
pmc: PMC8409465
mid: NIHMS1731242
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL086350
Pays : United States
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interest.
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