A study to understand the pattern of hyponatremia in patients using selective serotonin reuptake inhibitors and serotonin dopamine antagonists.
Hyponatremia
selective serotonin reuptake inhibitor
serotonin dopamine antagonist
Journal
Industrial psychiatry journal
ISSN: 0972-6748
Titre abrégé: Ind Psychiatry J
Pays: India
ID NLM: 101547239
Informations de publication
Date de publication:
Historique:
received:
20
07
2020
revised:
06
12
2020
accepted:
25
04
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
Hyponatremia can be a common but often overlooked side effects of psychotropics drugs. Most patients with drug-induced hyponatremia are asymptomatic and diagnosis is made incidentally following routine blood tests. The aim of the study was to understand the pattern of hyponatremia in patients using selective serotonin reuptake inhibitors (SSRI) and serotonin dopamine antagonists (SDA). All inpatients and outpatients who were diagnosed with International Classification of Diseases-10 psychiatric disorders and undergoing treatment with SSRI, SDA, or combination of both for the same, were included in the study after simple random sampling, subject to inclusion and exclusion criteria. Categorical variables were observed as numbers and percentages. Continuous variables were evaluated as mean ± standard deviation. A Chi-square test was done to find the association between categorical variables. SPSS (IBM) version 21 was used for data analysis. In 150 patients, we found hyponatremia in 17 patients (11.33%). About 66-75 age group patients had maximum found cases of hyponatremia (66.66%). About 20.31% of females found hyponatremia. Among SSRIs, 16% of individuals had hyponatremia whereas among SDA it was 6%. Patients who were taking both SSRIs and SDA total prevalence of hyponatremia was 12%. Older age groups and females had higher chances of hyponatremia while taking SSRIs and SDAs. Among SSRIs, escitalopram had maximum percentage of hyponatremia, whereas fluvoxamine had minimum. Among SDAs, risperidone had maximum percentage, whereas quetiapine had minimum percentage of hyponatremia. Patients who were taking both fluoxetine + olanzapine or fluoxetine + risperidone had higher percentage of hyponatremia.
Identifiants
pubmed: 34483534
doi: 10.4103/ipj.ipj_146_20
pii: IPJ-30-113
pmc: PMC8395548
doi:
Types de publication
Journal Article
Langues
eng
Pagination
113-117Informations de copyright
Copyright: © 2021 Industrial Psychiatry Journal.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
Références
Biol Psychiatry. 1987 Apr;22(4):453-62
pubmed: 3567260
Am J Kidney Dis. 2008 Jul;52(1):144-53
pubmed: 18468754
Ann Pharmacother. 2006 Sep;40(9):1618-22
pubmed: 16896026
J Clin Psychiatry. 2004 Dec;65(12):1722
pubmed: 15641882
Drugs Aging. 1996 Jun;8(6):430-5
pubmed: 8736626
Am J Ther. 2008 Sep-Oct;15(5):492-4
pubmed: 18806526
Br J Clin Pharmacol. 2002 Apr;53(4):363-9
pubmed: 11966666
Psychiatry Clin Neurosci. 2007 Feb;61(1):132-3
pubmed: 17239054
Exp Gerontol. 2003 Aug;38(8):843-53
pubmed: 12915206
Ann Clin Psychiatry. 1997 Sep;9(3):181-3
pubmed: 9339885
CNS Drugs. 1997 Feb;7(2):121-38
pubmed: 23338131
Int J Geriatr Psychiatry. 2002 Mar;17(3):231-7
pubmed: 11921151
Ann Pharmacother. 2003 Nov;37(11):1694-702
pubmed: 14565794
Neuropsychopharmacology. 1995 Apr;12(2):133-8
pubmed: 7779241
Int J Geriatr Psychiatry. 2000 Mar;15(3):282-3
pubmed: 10713589
Actas Esp Psiquiatr. 2013 Nov-Dec;41(6):361-4
pubmed: 24203508
Psychosomatics. 2002 May-Jun;43(3):241-2
pubmed: 12075041
J Clin Psychopharmacol. 2009 Apr;29(2):186-9
pubmed: 19512986
Drug Saf. 2010 Jul 1;33(7):569-78
pubmed: 20553058
Jpn J Psychiatry Neurol. 1992 Dec;46(4):883-9
pubmed: 1304613
Indian J Endocrinol Metab. 2011 Sep;15 Suppl 3:S208-15
pubmed: 22029026
Clin Epidemiol. 2011 Apr 01;3:133-8
pubmed: 21487452