Metabolomic Biomarkers Are Associated With Area of the Pons in Fragile X Premutation Carriers at Risk for Developing FXTAS.

area of the pons brain measures fragile X-associated tremor/ataxia syndrome lipids metabolic biomarkers premutation carriers

Journal

Frontiers in psychiatry
ISSN: 1664-0640
Titre abrégé: Front Psychiatry
Pays: Switzerland
ID NLM: 101545006

Informations de publication

Date de publication:
2021
Historique:
received: 06 04 2021
accepted: 21 07 2021
entrez: 6 9 2021
pubmed: 7 9 2021
medline: 7 9 2021
Statut: epublish

Résumé

Fragile X-associated tremor/ataxia syndrome (FXTAS) is a late adult-onset neurodegenerative disorder that affects movement and cognition in male and female carriers of a premutation allele (55-200 CGG repeats; PM) in the fragile X mental retardation (

Identifiants

pubmed: 34483988
doi: 10.3389/fpsyt.2021.691717
pmc: PMC8415564
doi:

Types de publication

Journal Article

Langues

eng

Pagination

691717

Subventions

Organisme : NIMH NIH HHS
ID : R01 MH078041
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS110100
Pays : United States

Informations de copyright

Copyright © 2021 Zafarullah, Durbin-Johnson, Fourie, Hessl, Rivera and Tassone.

Déclaration de conflit d'intérêts

DH has received funding from Novartis, Roche, Seaside Therapeutics LLC and Marinus Pharmaceuticals, Inc. for designing Fragile X clinical Trials. FT has received funding from Azrieli Foundation, Zynerba and Asuragen, Inc. for studies in Fragile X syndrome. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Références

Nat Med. 2014 Apr;20(4):415-8
pubmed: 24608097
AJNR Am J Neuroradiol. 2014 Nov-Dec;35(11):2099-105
pubmed: 24994832
Nat Rev Neurol. 2016 Jul;12(7):403-12
pubmed: 27340021
Hum Mol Genet. 2019 Mar 15;28(6):980-991
pubmed: 30476102
J Clin Psychiatry. 2006 Jan;67(1):87-94
pubmed: 16426093
Transl Psychiatry. 2013 Apr 09;3:e244
pubmed: 23571809
J Alzheimers Dis. 2017;60(3):809-817
pubmed: 27911300
Ann Neurol. 1999 Feb;45(2):265-9
pubmed: 9989633
Methods Mol Biol. 2019;1942:173-189
pubmed: 30900185
J Neurol Neurosurg Psychiatry. 2020 Dec;91(12):1329-1338
pubmed: 32928939
J Neurochem. 2017 Sep;142(5):756-766
pubmed: 28628213
J Cereb Blood Flow Metab. 2013 Oct;33(10):1493-9
pubmed: 23921897
Front Neurosci. 2018 Oct 25;12:784
pubmed: 30410433
Radiology. 2008 Jan;246(1):214-21
pubmed: 17991785
J Mol Diagn. 2008 Jan;10(1):43-9
pubmed: 18165273
Nat Rev Neurosci. 2009 Mar;10(3):211-23
pubmed: 19190638
Sci Rep. 2017 Oct 25;7(1):14038
pubmed: 29070876
Alzheimers Dement. 2017 Mar;13(3):236-246
pubmed: 27513978
J Proteome Res. 2018 Jul 6;17(7):2460-2469
pubmed: 29762036
Front Neurosci. 2018 Jun 25;12:379
pubmed: 29988561
Eur J Radiol. 2004 Sep;51(3):223-33
pubmed: 15294329
FASEB J. 2016 Oct;30(10):3334-3351
pubmed: 27335370
PLoS One. 2013 Oct 22;8(10):e77629
pubmed: 24167579
Neuroimage. 2009 Jul 1;46(3):677-82
pubmed: 19264138
Front Neurol. 2011 Jul 11;2:42
pubmed: 21808630
PLoS One. 2013 Sep 18;8(9):e73094
pubmed: 24058461
Biomark Med. 2014;8(9):1151-69
pubmed: 25402585
Adv Drug Deliv Rev. 2020;159:232-244
pubmed: 32360155
J Neurol. 2019 Apr;266(4):1036-1045
pubmed: 30460448
J Parkinsons Dis. 2014;4(3):549-60
pubmed: 24927756
Neurology. 2012 Oct 30;79(18):1898-907
pubmed: 23077007
Front Neurol. 2020 May 21;11:437
pubmed: 32528400
Anal Chem. 2009 Aug 15;81(16):6656-67
pubmed: 19624122
Arch Neurol. 2006 Jan;63(1):81-6
pubmed: 16401739
Radiology. 2006 Jun;239(3):825-30
pubmed: 16714464
Genome Med. 2012 Dec 21;4(12):100
pubmed: 23259642
Metallomics. 2015 Feb;7(2):363-70
pubmed: 25599126
Front Hum Neurosci. 2018 Jun 04;12:226
pubmed: 29915533
JAMA. 2004 Jan 28;291(4):460-9
pubmed: 14747503
J Clin Neurosci. 2016 Jan;23:162-164
pubmed: 26439425
Front Neurol. 2018 Jan 12;8:719
pubmed: 29375465
Mol Med. 2016 Oct;22:548-559
pubmed: 27385396
Nat Rev Neurosci. 2018 Jun;19(6):351-367
pubmed: 29740175
IEEE Trans Med Imaging. 2010 Jun;29(6):1310-20
pubmed: 20378467
PLoS One. 2015 Mar 24;10(3):e0119452
pubmed: 25803028
Neural Regen Res. 2019 Mar;14(3):387-390
pubmed: 30539802
Biochim Biophys Acta Mol Basis Dis. 2018 Jul;1864(7):2430-2437
pubmed: 29684586
ACS Chem Biol. 2014 Sep 19;9(9):2032-48
pubmed: 24937102
Sci Rep. 2017 Aug 4;7(1):7328
pubmed: 28779141
J Neurol. 2008 Jan;255(1):144-6
pubmed: 18080849
Alzheimers Dement. 2017 Sep;13(9):965-984
pubmed: 28341160
Sci Rep. 2020 Jul 6;10(1):11099
pubmed: 32632326
Front Neurol. 2019 Mar 18;10:191
pubmed: 30936848
PLoS One. 2016 Jan 25;11(1):e0147129
pubmed: 26808974
Biochem J. 2016 Nov 1;473(21):3871-3888
pubmed: 27555610
PLoS One. 2013 May 20;8(5):e63644
pubmed: 23700429
Front Aging Neurosci. 2018 Sep 11;10:266
pubmed: 30254583
FASEB J. 2020 Dec;34(12):16676-16692
pubmed: 33131090
Front Mol Neurosci. 2016 Aug 12;9:71
pubmed: 27570505
Parkinsonism Relat Disord. 2014 Feb;20(2):222-5
pubmed: 24239142
Alzheimers Dement. 2018 Mar;14(3):318-329
pubmed: 29055815
Nat Commun. 2020 Aug 11;11(1):4016
pubmed: 32782260
Nat Rev Neurosci. 2017 Mar 17;18(4):251-259
pubmed: 28303016
EMBO J. 2017 Jun 1;36(11):1474-1492
pubmed: 28438892
Mol Neurobiol. 2019 May;56(5):3702-3713
pubmed: 30187385
Oxid Med Cell Longev. 2019 May 9;2019:2105607
pubmed: 31210837
Curr Biol. 2012 Sep 11;22(17):R741-52
pubmed: 22975005
Neuroimage. 2005 Jul 1;26(3):912-21
pubmed: 15955501
Transl Neurodegener. 2017 Mar 28;6:8
pubmed: 28360997
Nat Rev Dis Primers. 2017 Sep 29;3:17065
pubmed: 28960184
Front Neurosci. 2018 Apr 17;12:249
pubmed: 29719499
Ann Clin Transl Neurol. 2019 Feb 21;6(3):525-536
pubmed: 30911576
Front Neurosci. 2018 Aug 30;12:612
pubmed: 30214392
J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):722-8
pubmed: 17353258
Clin Chem. 2010 Mar;56(3):399-408
pubmed: 20056738
Mol Neurodegener. 2019 Jan 11;14(1):3
pubmed: 30634989

Auteurs

Marwa Zafarullah (M)

Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA, United States.

Blythe Durbin-Johnson (B)

Division of Biostatistics, School of Medicine, University of California, Davis, Davis, CA, United States.

Emily S Fourie (ES)

Center for Mind and Brain, University of California, Davis, Davis, CA, United States.
Department of Psychology, University of California, Davis, Davis, CA, United States.

David R Hessl (DR)

MIND Institute, University of California, Davis Medical Center, Sacramento, CA, United States.
Department of Psychiatry and Behavioral Sciences, University of California, Davis Medical Center, Sacramento, CA, United States.

Susan M Rivera (SM)

Center for Mind and Brain, University of California, Davis, Davis, CA, United States.
Department of Psychology, University of California, Davis, Davis, CA, United States.
MIND Institute, University of California, Davis Medical Center, Sacramento, CA, United States.

Flora Tassone (F)

Department of Biochemistry and Molecular Medicine, University of California, Davis, School of Medicine, Sacramento, CA, United States.
MIND Institute, University of California, Davis Medical Center, Sacramento, CA, United States.

Classifications MeSH