Survival Analysis in Primary Progressive Apraxia of Speech and Agrammatic Aphasia.
Journal
Neurology. Clinical practice
ISSN: 2163-0402
Titre abrégé: Neurol Clin Pract
Pays: United States
ID NLM: 101577149
Informations de publication
Date de publication:
Jun 2021
Jun 2021
Historique:
received:
19
12
2019
accepted:
07
04
2020
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
To compare survival among patients with different combinations of apraxia of speech (AOS) and agrammatic aphasia, including those with isolated AOS (primary progressive AOS, PPAOS), both AOS and agrammatic aphasia (AOS + progressive agrammatic aphasia [PAA]), and isolated agrammatic aphasia (PAA). One hundred nine patients were recruited who had any combination of AOS and agrammatic aphasia (42 PPAOS, 56 AOS + PAA, and 11 PAA) and were followed longitudinally, with 57 patients having since died. Cox proportional hazard models were used to quantify the relative risk of death across diagnoses. Adjusted survival curves are presented based on this model. We also assessed the influence of AOS and aphasia severity on survival. PPAOS had the longest survival (median survival of 5.97 years from the baseline visit), followed by PAA (5.26 years) and then AOS + PAA (4.33 years). AOS + PAA had a greater risk of death than PPAOS, with a hazard ratio of 3.01 (lower/upper confidence interval = 1.66/5.46, Individuals with PPAOS have better survival and reduced risk of death compared with individuals with AOS + PAA. This finding will help improve prognostic estimates for these patients and supports the value of distinguishing PPAOS from AOS + PAA.
Identifiants
pubmed: 34484892
doi: 10.1212/CPJ.0000000000000919
pii: NEURCLINPRACT2019049148
pmc: PMC8382380
doi:
Types de publication
Journal Article
Langues
eng
Pagination
249-255Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC014942
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC012519
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS094684
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS089757
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC010367
Pays : United States
Informations de copyright
© 2021 American Academy of Neurology.
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