Coagulopathy in Acute Promyelocytic Leukemia: Can We Go Beyond Supportive Care?
APL
ATRA
delayed bleeding
hemorrhage
hyperfibrinolysis
thrombosis
Journal
Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047
Informations de publication
Date de publication:
2021
2021
Historique:
received:
09
06
2021
accepted:
26
07
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
epublish
Résumé
Acute promyelocytic leukemia (APL) is characterized by frequent complications due to a distinct coagulopathy. While advances in treatments have improved long-term survival, hemorrhagic and thrombotic complications remain the most common causes of death and morbidity. Improved understanding of the mechanisms of the coagulopathy associated with APL may lead to therapeutic interventions to mitigate the risk of hemorrhage and thrombosis.
Identifiants
pubmed: 34485349
doi: 10.3389/fmed.2021.722614
pmc: PMC8415964
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
722614Informations de copyright
Copyright © 2021 Hambley, Tomuleasa and Ghiaur.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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