Monolayer platform using human biopsy-derived duodenal organoids for pharmaceutical research.
CES1
CES2
CYP3A4
P-glycoprotein
PEPT1
intestinal first-pass effect
intestinal organoids
microarray
monolayer culture
small intestine
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
09
02
2021
accepted:
11
05
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
epublish
Résumé
The human small intestine is the key organ for absorption, metabolism, and excretion of orally administered drugs. To preclinically predict these reactions in drug discovery research, a cell model that can precisely recapitulate the
Identifiants
pubmed: 34485610
doi: 10.1016/j.omtm.2021.05.005
pii: S2329-0501(21)00089-9
pmc: PMC8399089
doi:
Types de publication
Journal Article
Langues
eng
Pagination
263-278Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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