Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.
CAR T cells
HIV
SIV
autologous cell therapy
humoral immune response
infectious diseases
Journal
Molecular therapy. Methods & clinical development
ISSN: 2329-0501
Titre abrégé: Mol Ther Methods Clin Dev
Pays: United States
ID NLM: 101624857
Informations de publication
Date de publication:
10 Sep 2021
10 Sep 2021
Historique:
received:
10
03
2021
accepted:
15
06
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
epublish
Résumé
Chimeric antigen receptor (CAR) T cell therapies are being investigated as potential HIV cures and designed to target HIV reservoirs. Monoclonal antibodies (mAbs) targeting the simian immunodeficiency virus (SIV) envelope allowed us to investigate the potency of single-chain variable fragment (scFv)-based anti-SIV CAR T cells.
Identifiants
pubmed: 34485613
doi: 10.1016/j.omtm.2021.06.008
pii: S2329-0501(21)00110-8
pmc: PMC8403686
doi:
Types de publication
Journal Article
Langues
eng
Pagination
304-319Subventions
Organisme : NIAID NIH HHS
ID : UM1 AI126623
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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