Pain after upper limb surgery under peripheral nerve block is associated with gut microbiome composition and diversity.
Gut microbiota
Nerve block
Rebound pain
Regional anaesthesia
Journal
Neurobiology of pain (Cambridge, Mass.)
ISSN: 2452-073X
Titre abrégé: Neurobiol Pain
Pays: United States
ID NLM: 101705141
Informations de publication
Date de publication:
Historique:
received:
24
11
2020
revised:
30
07
2021
accepted:
12
08
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
epublish
Résumé
Gut microbiota play a role in certain pain states. Hence, these microbiota also influence somatic pain. We aimed to determine if there was an association between gut microbiota (composition and diversity) and postoperative pain. Patients (n = 20) undergoing surgical fixation of distal radius fracture under axillary brachial plexus block were studied. Gut microbiota diversity and abundance were analysed for association with: (i) a verbal pain rating scale of < 4/10 throughout the first 24 h after surgery (ii) a level of pain deemed "acceptable" by the patient during the first 24 h following surgery (iii) a maximum self-reported pain score during the first 24 h postoperatively and (iv) analgesic consumption during the first postoperative week. Analgesic consumption was inversely correlated with the Shannon index of alpha diversity. There were also significant differences, at the genus level (including
Identifiants
pubmed: 34485761
doi: 10.1016/j.ynpai.2021.100072
pii: S2452-073X(21)00013-1
pmc: PMC8404729
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100072Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors. George Shorten is a funded investigator, Insight II SFI Research Centre.
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