A review of therapies for the overlap syndrome of obstructive sleep apnea and chronic obstructive pulmonary disease.
COPD
OSA
PAP therapy
overlap syndrome
phenotype
sleep‐disordered breathing
Journal
FASEB bioAdvances
ISSN: 2573-9832
Titre abrégé: FASEB Bioadv
Pays: United States
ID NLM: 101733210
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
15
02
2021
revised:
13
05
2021
accepted:
14
05
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
epublish
Résumé
Obstructive sleep apnea (OSA) and chronic obstructive pulmonary disease (COPD) are common chronic diseases. These two noncommunicable diseases (NCDs) are prevalent among approximately 10% of the general population. Approximately 1% of the population is affected by the co-existence of both conditions, known as the overlap syndrome (OS). OS patients suffer from greater degrees of nocturnal oxygen desaturation and cardiovascular consequences than those with either condition in isolation. Besides OS, patients with COPD may suffer from a spectrum of sleep-related breathing disorders, including hypoventilation and central sleep apnea. The article provides an overview of the pathogenesis, associated risk factors, prevalence, and management of sleep-related breathing disorders in COPD. It examines respiratory changes during sleep caused by COPD and OSA. It elaborates upon the factors that link the two conditions together to lead to OS. It also discusses the clinical evaluation and diagnosis of these patients. Subsequently, it reviews the pathophysiological basis and the current evidence for three potential therapies: positive airway pressure therapy [including continuous positive airway pressure (CPAP) and bilevel positive airway pressure], oxygen therapy, and pharmacological therapy. It also proposes a phenotypic approach toward the diagnosis and treatment of OS and the entire spectrum of sleep-related breathing disorders in COPD. It concludes with the current evidence gaps and future areas of research in the management of OS.
Identifiants
pubmed: 34485837
doi: 10.1096/fba.2021-00024
pii: FBA21252
pmc: PMC8409567
doi:
Types de publication
Journal Article
Langues
eng
Pagination
683-693Informations de copyright
© 2021 The Authors. FASEB BioAdvances published by the Federation of American Societies for Experimental Biology.
Déclaration de conflit d'intérêts
There are no conflicts of interest.
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