Surgical protocol for permanent ligation of the left anterior descending coronary artery in mice to generate a model of myocardial infarction.

Animals Cardiovascular Surgical Procedures / methods Coronary Vessels / surgery Disease Models, Animal Ligation / methods Male Mice Mice, Inbred C57BL Models, Cardiovascular Myocardial Infarction
Cell Biology Health Sciences Model Organisms

Journal

STAR protocols
ISSN: 2666-1667
Titre abrégé: STAR Protoc
Pays: United States
ID NLM: 101769501

Informations de publication

Date de publication:
17 09 2021
Historique:
entrez: 6 9 2021
pubmed: 7 9 2021
medline: 7 9 2021
Statut: epublish

Résumé

Myocardial infarction (MI) is one of the most common causes of death worldwide. Animal models for MI are useful for studying the pathophysiology and developing therapies. Here, we describe a surgical protocol for permanent ligation of the left anterior descending coronary artery in mice, which mimics human acute coronary syndrome. This protocol includes descriptive step-by-step surgical procedures and high-quality surgical videos, which are useful for performing stable and highly reproducible operations. For complete details on the use and execution of this protocol, please refer to Maruyama et al. (2021).

Identifiants

DOI: 10.1016/j.xpro.2021.100775 PMID: 34485941 PMC: PMC8403767
pubmed: 34485941
doi: 10.1016/j.xpro.2021.100775
pii: S2666-1667(21)00481-0
pmc: PMC8403767
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

100775

Informations de copyright

© 2021 The Author(s).

Déclaration de conflit d'intérêts

The authors declare no competing interests.

Références

iScience. 2021 Mar 15;24(4):102305
pubmed: 33870127

Auteurs

Kazuaki Maruyama (K)

Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi Tsu, Mie 514-8507, Japan.

Kazuaki Naemura (K)

Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Kenji Yoshihara (K)

Heart Center, Department of Pediatric Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.

Kyoko Imanaka-Yoshida (K)

Department of Pathology and Matrix Biology, Graduate School of Medicine, Mie University Graduate School of Medicine, 2-174 Edobashi Tsu, Mie 514-8507, Japan.

Hiroki Kurihara (H)

Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Sachiko Miyagawa-Tomita (S)

Department of Physiological Chemistry and Metabolism, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Heart Center, Department of Pediatric Cardiology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Department of Animal Nursing Science, Yamazaki University of Animal Health Technology, 4-7-2 Minami-Osawa, Hachioji, Tokyo 192-0364, Japan.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Surgical protocol for permanent ligation of...
questionsmedicales.fr › Procédures de chirurgie opératoire › Procédures de chirurgie cardiovasculaire › Surgical protocol for permanent ligation of...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Veines › Vaisseaux coronaires › Surgical protocol for permanent ligation of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Surgical protocol for permanent ligation of...
questionsmedicales.fr › Procédures de chirurgie opératoire › Ligature › Surgical protocol for permanent ligation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Surgical protocol for permanent ligation of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Surgical protocol for permanent ligation of...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles cardiovasculaires › Surgical protocol for permanent ligation of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Nécrose › Infarctus › Infarctus du myocarde › Surgical protocol for permanent ligation of...