Nanoparticles-assisted delivery of antiviral-siRNA as inhalable treatment for human respiratory viruses: A candidate approach against SARS-COV-2.
Corona pandemic
SARS‐CoV‐2
human respiratory viruses
lipid nanoparticles
multifunctional nanocarriers
siRNA delivery
Journal
Nano select : open access
ISSN: 2688-4011
Titre abrégé: Nano Sel
Pays: Germany
ID NLM: 9918249608306676
Informations de publication
Date de publication:
Dec 2020
Dec 2020
Historique:
received:
31
08
2020
accepted:
25
09
2020
pubmed:
7
9
2021
medline:
7
9
2021
entrez:
6
9
2021
Statut:
ppublish
Résumé
The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has challenged healthcare structures across the globe. Although a few therapies are approved by FDA, the search for better treatment options is continuously on rise. Clinical management includes infection prevention and supportive care such as supplemental oxygen and mechanical ventilatory support. Given the urgent nature of the pandemic and the number of companies and researchers developing COVID-19 related therapies, FDA has created an emergency program to move potential treatments with already approved drugs to patients as quickly as possible in parallel to the development of new drugs that must first pass the clinical trials. In this manuscript, we have reviewed the available literature on the use of sequence-specific degradation of viral genome using short-interfering RNA (siRNA) suggesting it as a possible treatment against SARS-CoV-2. Delivery of siRNA can be promoted by the use of FDA approved lipids, polymers or lipid-polymer hybrids. These nanoparticulate systems can be engineered to exhibit increased targetability and formulated as inhalable aerosols.
Identifiants
pubmed: 34485978
doi: 10.1002/nano.202000125
pii: NANO202000125
pmc: PMC7675679
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
612-621Informations de copyright
© 2020 The Authors. Nano Select published by Wiley‐VCH GmbH.
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