Presence of IgE Autoantibodies Against Eosinophil Peroxidase and Eosinophil Cationic Protein in Severe Chronic Spontaneous Urticaria and Atopic Dermatitis.
Allergy
atopic dermatitis
autoantibodies
chronic urticaria
eosinophil cationic protein
eosinophil peroxidase
immunoglobulin E
peroxidase
thyroperoxidase
Journal
Allergy, asthma & immunology research
ISSN: 2092-7355
Titre abrégé: Allergy Asthma Immunol Res
Pays: Korea (South)
ID NLM: 101518382
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
04
10
2020
revised:
17
12
2020
accepted:
17
12
2020
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
Eosinophils are frequently found in atopic dermatitis (AD) and chronic spontaneous urticaria (CSU) that release eosinophil peroxidase (EPX) and eosinophil cationic protein (ECP). Continuous exposure to these proteins could trigger an autoimmune response which may contribute to the pathogenesis and severity of skin inflammation. In this study, we investigate the immunoglobulin E (IgE) response against eosinophil proteins in CSU and AD. We recruited patients with severe AD, severe CSU and healthy subjects to explore the presence of IgE autoantibodies and cross-reactivity against EPX, ECP and thyroid peroxidase (TPO). The potential cross-reactive epitopes among the peroxidase family were determined using The frequencies of anti-EPX IgE (28.8%) and anti-ECP IgE (26.6%) were higher in the AD group, and anti-TPO IgE was higher in the CSU group (27.2%). In the CSU group, there was a correlation between the anti-EPX IgE and anti-TPO IgE levels ( IgE against eosinophil proteins may contribute to chronic inflammation in patients with AD and CSU. Cross-reactivity between EPX and TPO could explain thyroid problems in CSU patients.
Identifiants
pubmed: 34486259
pii: 13.746
doi: 10.4168/aair.2021.13.5.746
pmc: PMC8419645
doi:
Types de publication
Journal Article
Langues
eng
Pagination
746-761Subventions
Organisme : IPS Universitaria
Pays : Colombia
Organisme : Unidad Alergologíca
Pays : Colombia
Organisme : San Vicente de Paul
Pays : Colombia
Organisme : Universidad de Antioquia
Pays : Colombia
Informations de copyright
Copyright © 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease.
Déclaration de conflit d'intérêts
There are no financial or other issues that might lead to conflict of interest.
Références
J Biol Chem. 1996 Mar 1;271(9):4966-73
pubmed: 8617771
Clin Exp Allergy. 1991 Nov;21(6):695-704
pubmed: 1723343
Clin Immunol. 2005 Mar;114(3):284-92
pubmed: 15721839
Rev Alerg Mex. 2018 Jul-Sep;65(3):250-258
pubmed: 30176203
Allergy. 2018 Jul;73(7):1393-1414
pubmed: 29336054
J Allergy Clin Immunol Pract. 2020 Jan;8(1):318-325.e5
pubmed: 31472293
Science. 1991 Aug 2;253(5019):557-60
pubmed: 1857985
Int Arch Allergy Immunol. 2013;161 Suppl 2:154-8
pubmed: 23711867
J Allergy Clin Immunol. 2002 Apr;109(4):694-700
pubmed: 11941321
Arch Dermatol Res. 1995;287(2):180-5
pubmed: 7539247
Front Immunol. 2017 Dec 20;8:1845
pubmed: 29326719
Int J Immunopathol Pharmacol. 2011 Jan-Mar;24(1):15-23
pubmed: 21496383
J Allergy Clin Immunol. 2018 Mar;141(3):1165-1166
pubmed: 29102068
Mediators Inflamm. 1996;5(2):113-5
pubmed: 18475708
FASEB J. 1998 Nov;12(14):1559-69
pubmed: 9806765
Rev Alerg Mex. 2014 Jul-Sep;61(3):178-211
pubmed: 25177854
Skin Pharmacol. 1991;4 Suppl 1:64-70
pubmed: 1722416
Mol Cell Proteomics. 2016 Apr;15(4):1360-80
pubmed: 26831522
J Eur Acad Dermatol Venereol. 2018 Jun;32(6):850-878
pubmed: 29878606
Actas Dermosifiliogr. 2013 Jan;104(1):44-52
pubmed: 22841507
J Invest Dermatol. 2002 Oct;119(4):820-9
pubmed: 12406326
J Allergy Clin Immunol. 2018 Apr;141(4):1269-1279
pubmed: 28751233
Endocrinology. 2020 Feb 1;161(2):
pubmed: 32022847
J Immunol Res. 2019 Dec 7;2019:4202145
pubmed: 31886301
PLoS One. 2011 Apr 12;6(4):e14794
pubmed: 21532759
An Bras Dermatol. 2017 Mar-Apr;92(2):177-183
pubmed: 28538875
J Eur Acad Dermatol Venereol. 2018 May;32(5):657-682
pubmed: 29676534
Endocrinology. 2004 Aug;145(8):3671-8
pubmed: 15123538
Structure. 1997 Jan 15;5(1):33-45
pubmed: 9016715
J Korean Med Sci. 2015 Jun;30(6):705-9
pubmed: 26028921
Allergy. 2009 Nov;64(11):1635-43
pubmed: 19624559
Int Arch Allergy Immunol. 1999 Oct;120(2):117-25
pubmed: 10545765
Int Arch Allergy Immunol. 2010;152(4):401-6
pubmed: 20197682
JAMA Dermatol. 2019 Jan 1;155(1):50-57
pubmed: 30427975
Exp Dermatol. 2003 Oct;12(5):621-8
pubmed: 14705803
J Invest Dermatol. 1998 Dec;111(6):1178-83
pubmed: 9856836
J Allergy Clin Immunol. 2018 Sep;142(3):876-882
pubmed: 29208545
Immunol Lett. 2020 Apr;220:71-78
pubmed: 32027873
Allergy. 2009 Nov;64(11):1616-22
pubmed: 19485983
Allergy. 2001 Aug;56(8):780-4
pubmed: 11488674
Rev Alerg Mex. 2017 Jul-Sep;64(3):260-269
pubmed: 29046024
Autoimmun Rev. 2017 Dec;16(12):1196-1208
pubmed: 29037900
J Allergy Clin Immunol Pract. 2017 Mar - Apr;5(2):464-470
pubmed: 27838325
J Allergy Clin Immunol Pract. 2018 Jan - Feb;6(1):177-182.e1
pubmed: 28709817
Front Immunol. 2018 Apr 09;9:689
pubmed: 29686678
J Allergy Clin Immunol. 2009 Aug;124(2):278-85, 285.e1-7
pubmed: 19541355
J Eur Acad Dermatol Venereol. 2018 Mar;32(3):441-448
pubmed: 28846158
J Dermatol Sci. 1997 Aug;15(2):89-94
pubmed: 9279689
J Allergy Clin Immunol. 2020 Jun;145(6):1510-1516
pubmed: 32224275
Clin Exp Immunol. 1991 Oct;86(1):56-60
pubmed: 1717189
Allergy Asthma Immunol Res. 2019 Jan;11(1):29-42
pubmed: 30479075
Pediatr Pulmonol. 1998 Mar;25(3):167-74
pubmed: 9556008
Arch Biochem Biophys. 2006 Jan 15;445(2):199-213
pubmed: 16288970
Korean J Intern Med. 2018 Jan;33(1):185-192
pubmed: 27243229
Clin Exp Dermatol. 2019 Jun;44(4):376-380
pubmed: 30706507
Scand J Immunol. 1997 Jul;46(1):78-85
pubmed: 9246211
PLoS One. 2014 Feb 28;9(2):e90424
pubmed: 24587356
J Allergy Clin Immunol. 2005 May;115(5):1068-75
pubmed: 15867868
Immunology. 1989 Jun;67(2):197-204
pubmed: 2546881
Br J Dermatol. 2014 Sep;171(3):505-11
pubmed: 24665899
Endocrinology. 2005 Nov;146(11):4961-7
pubmed: 16081633