Limited Clinical Utility of Lipid-Laden Macrophage Index of Induced Sputum in Predicting Gastroesophageal Reflux-Related Cough.
Cough
diagnosis
gastroesophageal reflux
macrophages
sputum
Journal
Allergy, asthma & immunology research
ISSN: 2092-7355
Titre abrégé: Allergy Asthma Immunol Res
Pays: Korea (South)
ID NLM: 101518382
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
07
10
2020
revised:
14
02
2021
accepted:
23
02
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
ppublish
Résumé
Gastroesophageal reflux disease (GERD) is a common cause of chronic cough (CC). However, the diagnosis of GERD associated with CC based on 24-hour esophageal pH-monitoring or favorable response to empirical anti-reflux trials is invasive and time-consuming. Lipid-laden macrophages (LLMs) are supposed to be a biomarker for micro-aspiration of gastric content in the respiratory tract. This study was conducted to collect LLMs by the sputum induction technique and observe the relationship among the amount of LLMs, cough severity, parameters of 24-hour esophageal pH-monitoring and therapeutic response. The 24-hour esophageal pH-monitoring and sputum induction were performed on 57 patients with suspected GERD associated with CC. Thirty-four patients were followed up after empirical anti-reflux trials of 8 weeks to record the therapeutic response. Lipid-laden macrophage index (LLMI), a semiquantitative counting of LLMs, showed no significant correlation with the values of 24-hour esophageal pH monitoring at the proximal or remote electrode. No difference in LLMI or DeMeester score, as well as cough symptom association probability, were found between the responders and the non-responders. Reflux symptoms were more common in the responders (50%) compared to the non-responders (6%) (
Identifiants
pubmed: 34486263
pii: 13.799
doi: 10.4168/aair.2021.13.5.799
pmc: PMC8419643
doi:
Types de publication
Journal Article
Langues
eng
Pagination
799-807Subventions
Organisme : National Natural Science Foundation of China
ID : 81870079
Pays : China
Organisme : State Key Laboratory of Respiratory Disease
ID : SKLRD-QN-201702
Pays : China
Organisme : Incubative Project for Innovation Team of GMU
ID : 2017-159
Pays : China
Organisme : Undergraduate Innovation and Entrepreneurship Training Program of Guangdong Province
ID : 201810570041
Pays : China
Informations de copyright
Copyright © 2021 The Korean Academy of Asthma, Allergy and Clinical Immunology • The Korean Academy of Pediatric Allergy and Respiratory Disease.
Déclaration de conflit d'intérêts
There are no financial or other issues that might lead to conflict of interest.
Références
Respir Med. 2011 Aug;105(8):1257-61
pubmed: 21592756
Pediatrics. 2008 Apr;121(4):e879-84
pubmed: 18362101
Pulm Med. 2012;2012:673637
pubmed: 22448325
Lancet. 2008 Apr 19;371(9621):1364-74
pubmed: 18424325
Chest. 2016 Dec;150(6):1341-1360
pubmed: 27614002
Lancet Respir Med. 2013 Jul;1(5):414-22
pubmed: 24429206
World J Methodol. 2015 Sep 26;5(3):149-56
pubmed: 26413488
Front Physiol. 2018 May 15;9:536
pubmed: 29867575
Chest. 2012 Oct;142(4):958-964
pubmed: 22797535
Am Rev Respir Dis. 1985 Sep;132(3):576-81
pubmed: 4037530
J Neurogastroenterol Motil. 2017 Jan 30;23(1):41-48
pubmed: 27605525
Arch Med Res. 2005 Sep-Oct;36(5):485-9
pubmed: 16099326
Eur Respir J. 2002 Aug;20(2):268-73
pubmed: 12212954
Eur Respir J. 2000 Dec;16(6):1119-22
pubmed: 11292116
Neurogastroenterol Motil. 2012 Feb;24(2):129-33, e84-5
pubmed: 22141343
Respir Med. 2014 Jan;108(1):71-7
pubmed: 24172051
Eur Respir J. 2020 Jan 2;55(1):
pubmed: 31515408
N Engl J Med. 2019 Oct 10;381(15):1488-1489
pubmed: 31491073
Inflammation. 2013 Apr;36(2):493-500
pubmed: 23225164
Int J Exp Pathol. 1991 Aug;72(4):423-35
pubmed: 1883742
Gut. 2017 Dec;66(12):2057-2062
pubmed: 28298354
J Thorac Dis. 2018 Nov;10(11):6314-6351
pubmed: 30622806
Chest. 2006 Jan;129(1 Suppl):80S-94S
pubmed: 16428697
Gastroenterology. 2018 Jan;154(2):277-288
pubmed: 29037470