Integrated evaluation of telomerase activation and telomere maintenance across cancer cell lines.
CCLE
cancer
cancer biology
cell lines
computational biology
genetics
genomics
human
systems biology
telomeres
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
06 09 2021
06 09 2021
Historique:
received:
02
01
2021
accepted:
27
08
2021
pubmed:
7
9
2021
medline:
1
12
2021
entrez:
6
9
2021
Statut:
epublish
Résumé
In cancer, telomere maintenance is critical for the development of replicative immortality. Using genome sequences from the Cancer Cell Line Encyclopedia and Genomics of Drug Sensitivity in Cancer Project, we calculated telomere content across 1299 cancer cell lines. We find that telomerase reverse transcriptase (
Identifiants
pubmed: 34486523
doi: 10.7554/eLife.66198
pii: 66198
pmc: PMC8530513
doi:
pii:
Substances chimiques
Telomerase
EC 2.7.7.49
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Hu et al.
Déclaration de conflit d'intérêts
KH, FH No competing interests declared, MG MG is an employee and holds equity in Monte Rosa Therapeutics and is a founding member at Cambridge Data Science LLC.
Références
Genes Dev. 2005 Sep 15;19(18):2100-10
pubmed: 16166375
Nat Rev Mol Cell Biol. 2007 Dec;8(12):983-94
pubmed: 18037899
BMC Bioinformatics. 2019 May 28;20(1):272
pubmed: 31138115
Nat Med. 1997 Nov;3(11):1271-4
pubmed: 9359704
Science. 2009 Nov 13;326(5955):948-52
pubmed: 19965504
Cancer Res. 2000 Nov 15;60(22):6230-5
pubmed: 11103775
Nature. 2019 May;569(7757):503-508
pubmed: 31068700
Elife. 2015 Jul 21;4:
pubmed: 26194807
Science. 2013 Feb 22;339(6122):957-9
pubmed: 23348506
Nucleic Acids Res. 2019 Jan 8;47(D1):D941-D947
pubmed: 30371878
Cancer Sci. 2008 Jun;99(6):1092-9
pubmed: 18482052
Nucleic Acids Res. 2018 Jul 2;46(W1):W194-W199
pubmed: 29878235
Nature. 2012 Mar 28;483(7391):603-7
pubmed: 22460905
PLoS One. 2018 Sep 18;13(9):e0204159
pubmed: 30226859
Science. 2013 Feb 22;339(6122):959-61
pubmed: 23348503
Mol Cell Biol. 1999 Jan;19(1):567-76
pubmed: 9858580
Nat Biotechnol. 2013 Mar;31(3):213-9
pubmed: 23396013
Nat Rev Mol Cell Biol. 2003 Dec;4(12):975-80
pubmed: 14685175
Genome Biol. 2020 Sep 11;21(1):234
pubmed: 32912332
PLoS Biol. 2016 Dec 15;14(12):e2000016
pubmed: 27977688
Science. 1994 Dec 23;266(5193):2011-5
pubmed: 7605428
Nature. 2012 Aug 23;488(7412):540-4
pubmed: 22763445
Science. 2017 Sep 29;357(6358):1416-1420
pubmed: 28818973
Nat Commun. 2020 Feb 5;11(1):733
pubmed: 32024817
Nature. 2007 Jun 21;447(7147):924-31
pubmed: 17581575
Cell. 1985 Dec;43(2 Pt 1):405-13
pubmed: 3907856
PLoS Genet. 2012;8(7):e1002772
pubmed: 22829774
PLoS One. 2016 Feb 09;11(2):e0148793
pubmed: 26859482
EMBO J. 2001 Dec 17;20(24):6958-68
pubmed: 11742973
BMC Genomics. 2009 Mar 31;10:143
pubmed: 19335899
Bioinformatics. 2016 Feb 15;32(4):587-9
pubmed: 26508757
Cell Syst. 2018 May 23;6(5):555-568.e7
pubmed: 29778836
Nat Commun. 2015 Jul 06;6:7538
pubmed: 26143912
Cells. 2019 Jan 31;8(2):
pubmed: 30709063
Cancer Discov. 2016 Nov;6(11):1276-1291
pubmed: 27650951
J Theor Biol. 1973 Sep 14;41(1):181-90
pubmed: 4754905
Nucleic Acids Res. 2018 Jun 1;46(10):4903-4918
pubmed: 29718321
Oncogenesis. 2015 Dec 14;4:e176
pubmed: 26657580
Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18488-18497
pubmed: 31451652
Nat Biotechnol. 2020 Jun;38(6):675-678
pubmed: 32444850
Nat Genet. 1999 Feb;21(2):220-4
pubmed: 9988278
Nucleic Acids Res. 2014 May;42(9):e75
pubmed: 24609383
Cancer Cell. 2019 Feb 11;35(2):315-328.e6
pubmed: 30753828
Nat Rev Genet. 2010 May;11(5):319-30
pubmed: 20351727
Cancer Res. 2013 May 1;73(9):2817-28
pubmed: 23610451
Cancer Cell. 2015 Sep 14;28(3):357-69
pubmed: 26373281
Curr Opin Genet Dev. 2020 Feb;60:56-62
pubmed: 32163830
Am J Pathol. 2011 Oct;179(4):1608-15
pubmed: 21888887
J Clin Invest. 2019 Apr 1;129(4):1801
pubmed: 30932912
Science. 2009 Jan 30;323(5914):644-8
pubmed: 19179534
Nucleic Acids Res. 2013 Jan;41(Database issue):D955-61
pubmed: 23180760
Oncogene. 2002 Jan 21;21(4):619-26
pubmed: 11850787
Nat Genet. 2017 Mar;49(3):349-357
pubmed: 28135248
Differentiation. 2018 Jan - Feb;99:1-9
pubmed: 29197683
Science. 2020 Sep 11;369(6509):
pubmed: 32913074
Science. 2011 Jul 22;333(6041):425
pubmed: 21719641
Mol Oncol. 2020 Oct;14(10):2358-2374
pubmed: 33245585
Genes Dev. 2015 Nov 1;29(21):2219-24
pubmed: 26515115
PLoS One. 2013 Dec 06;8(12):e81148
pubmed: 24324667
Science. 2015 Jan 16;347(6219):273-7
pubmed: 25593184
Nat Genet. 2017 Dec;49(12):1779-1784
pubmed: 29083409
Cancer Res. 2005 Sep 1;65(17):7866-73
pubmed: 16140956
Science. 2012 Jun 22;336(6088):1519-20
pubmed: 22723405
Cell. 2017 Jul 27;170(3):577-592.e10
pubmed: 28753431
Mol Biol Cell. 2004 Jan;15(1):81-90
pubmed: 14528011
Curr Protoc Bioinformatics. 2013;43:11.10.1-11.10.33
pubmed: 25431634
Cell. 2017 Jul 27;170(3):564-576.e16
pubmed: 28753430
Cell. 2020 Jan 23;180(2):387-402.e16
pubmed: 31978347
PLoS One. 2020 Apr 8;15(4):e0231418
pubmed: 32267900
Oncogene. 2019 Aug;38(34):6172-6183
pubmed: 31285550
Proc Natl Acad Sci U S A. 1942 Nov;28(11):458-63
pubmed: 16578057
J Biol Chem. 2009 Sep 25;284(39):26725-31
pubmed: 19648609
Genetics. 1941 Mar;26(2):234-82
pubmed: 17247004
Science. 1995 Sep 1;269(5228):1236-41
pubmed: 7544491
Nature. 1990 Mar 8;344(6262):126-32
pubmed: 1689810
Cancer Res. 1998 Apr 1;58(7):1558-61
pubmed: 9537264
Proc Natl Acad Sci U S A. 2013 Apr 9;110(15):6021-6
pubmed: 23530248
Science. 2015 May 29;348(6238):1036-9
pubmed: 25977370
Cell Rep. 2017 Dec 26;21(13):3700-3707
pubmed: 29281820