A lesson from the wild: The natural state of eosinophils is Ly6G
Ly6G
ecoimmunology
eosinophils
flow cytometry
granulocytes
phenotype
wild mice
Journal
Immunology
ISSN: 1365-2567
Titre abrégé: Immunology
Pays: England
ID NLM: 0374672
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
29
08
2021
received:
12
07
2021
accepted:
02
09
2021
pubmed:
7
9
2021
medline:
15
12
2021
entrez:
6
9
2021
Statut:
ppublish
Résumé
With a long history of promoting pathological inflammation, eosinophils are now emerging as important regulatory cells. Yet, findings from controlled laboratory experiments so far lack translation to animals, including humans, in their natural environment. In order to appreciate the breadth of eosinophil phenotype under non-laboratory, uncontrolled conditions, we exploit a free-living population of the model organism Mus musculus domesticus. Eosinophils were present at significantly higher proportions in the spleen and bone marrow of wild mice compared with laboratory mice. Strikingly, the majority of eosinophils of wild mice exhibited a unique Ly6G
Identifiants
pubmed: 34486729
doi: 10.1111/imm.13413
pmc: PMC8561109
doi:
Substances chimiques
Antigens, Ly
0
Biomarkers
0
Ly6G antigen, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
766-776Subventions
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/P018157/1
Pays : United Kingdom
Informations de copyright
© 2021 The Authors. Immunology published by John Wiley & Sons Ltd.
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