Discovery of a transdermally deliverable pentapeptide for activating AdipoR1 to promote hair growth.
adiponectin
adiponectin receptor 1
adiponectin receptor 1 agonist
hair growth
peptide
Journal
EMBO molecular medicine
ISSN: 1757-4684
Titre abrégé: EMBO Mol Med
Pays: England
ID NLM: 101487380
Informations de publication
Date de publication:
07 10 2021
07 10 2021
Historique:
revised:
30
07
2021
received:
02
12
2020
accepted:
20
08
2021
pubmed:
7
9
2021
medline:
26
10
2021
entrez:
6
9
2021
Statut:
ppublish
Résumé
Alopecia induced by aging or side effects of medications affects millions of people worldwide and impairs the quality of life; however, there is a limit to the current medications. Here, we identify a small transdermally deliverable 5-mer peptide (GLYYF; P5) that activates adiponectin receptor 1 (AdipoR1) and promotes hair growth. P5 sufficiently reproduces the biological effect of adiponectin protein via AMPK signaling pathway, increasing the expression of hair growth factors in the dermal papilla cells of human hair follicle. P5 accelerates hair growth ex vivo and induces anagen hair cycle in mice in vivo. Furthermore, we elucidate a key spot for the binding between AdipoR1 and adiponectin protein using docking simulation and mutagenesis studies. This study suggests that P5 could be used as a topical peptide drug for alleviating pathological conditions, which can be improved by adiponectin protein, such as alopecia.
Identifiants
pubmed: 34486824
doi: 10.15252/emmm.202013790
pmc: PMC8495455
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e13790Informations de copyright
© 2021 The Authors. Published under the terms of the CC BY 4.0 license.
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