Associations of Diet Quality with Midlife Brain Volume: Findings from the UK Biobank Cohort Study.
Aging
/ physiology
Brain
/ diagnostic imaging
Cohort Studies
Diet, Healthy
/ statistics & numerical data
Diet, Mediterranean
/ statistics & numerical data
Female
Gray Matter
/ diagnostic imaging
Hippocampus
/ diagnostic imaging
Humans
Image Processing, Computer-Assisted
/ statistics & numerical data
Magnetic Resonance Imaging
Male
Middle Aged
Surveys and Questionnaires
United Kingdom
White Matter
/ diagnostic imaging
Alzheimer’s disease
Mediterranean diet
brain volume
dementia
healthy diet
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2021
2021
Historique:
pubmed:
7
9
2021
medline:
5
1
2022
entrez:
6
9
2021
Statut:
ppublish
Résumé
Higher quality diets may be related to lower dementia rates. Midlife is emerging as a critical life stage for a number of dementia risk factors. This study examines whether diet quality is related to brain structure during midlife, and if this differs by sex. This study used data from 19184 UK Biobank participants aged 40-65 years. Diet quality was assessed using three dietary indices including the Mediterranean Diet Score (MDS), Healthy Diet Score (HDS), and Recommended Food Score (RFS). MRI brain measures included total, grey, white and hippocampal volume. Linear regression examined associations between diet quality and brain volume, controlling for potential confounders. Better quality diet across all indices was significantly related to larger grey matter volume: MDS β= 429.7 (95%CI: 65.2, 794.2); HDS β= 700.1 (348.0, 1052.1); and RFS β= 317.1 (106.8, 527.3). Higher diet scores were associated with greater total volume: HDS β= 879.32 (286.13, 1472.50); RFS β= 563.37 (209.10, 917.65); and white matter volume: RFS β= 246.31 (20.56, 472.05), with the exception of Mediterranean diet adherence. Healthy eating guidelines and dietary variety associations with total and grey matter volume were more prominent in men. Findings suggest that diet quality is associated with brain structure during midlife, potentially decades prior to the onset of dementia.
Sections du résumé
BACKGROUND
Higher quality diets may be related to lower dementia rates. Midlife is emerging as a critical life stage for a number of dementia risk factors.
OBJECTIVE
This study examines whether diet quality is related to brain structure during midlife, and if this differs by sex.
METHODS
This study used data from 19184 UK Biobank participants aged 40-65 years. Diet quality was assessed using three dietary indices including the Mediterranean Diet Score (MDS), Healthy Diet Score (HDS), and Recommended Food Score (RFS). MRI brain measures included total, grey, white and hippocampal volume. Linear regression examined associations between diet quality and brain volume, controlling for potential confounders.
RESULTS
Better quality diet across all indices was significantly related to larger grey matter volume: MDS β= 429.7 (95%CI: 65.2, 794.2); HDS β= 700.1 (348.0, 1052.1); and RFS β= 317.1 (106.8, 527.3). Higher diet scores were associated with greater total volume: HDS β= 879.32 (286.13, 1472.50); RFS β= 563.37 (209.10, 917.65); and white matter volume: RFS β= 246.31 (20.56, 472.05), with the exception of Mediterranean diet adherence. Healthy eating guidelines and dietary variety associations with total and grey matter volume were more prominent in men.
CONCLUSION
Findings suggest that diet quality is associated with brain structure during midlife, potentially decades prior to the onset of dementia.
Identifiants
pubmed: 34487048
pii: JAD210705
doi: 10.3233/JAD-210705
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
79-90Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom