Colloid carcinoma derived from intraductal papillary mucinous neoplasm of the pancreatic head with calcification: A case report and literature review.
Calcification
Chronic pancreatitis
Colloid carcinoma
IPMN
Osseous metaplasia
Journal
Surgical case reports
ISSN: 2198-7793
Titre abrégé: Surg Case Rep
Pays: Germany
ID NLM: 101662125
Informations de publication
Date de publication:
06 Sep 2021
06 Sep 2021
Historique:
received:
03
08
2021
accepted:
29
08
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
epublish
Résumé
Colloid carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreatic head with prominent calcification is exceedingly rare. Only a few studies about this entity have been reported in the literature. Therefore, its biological behavior, appropriate treatment modalities, and overall patient prognosis remain largely unclear. In this report, we present a case of a resected colloid carcinoma derived from IPMN with prominent calcification. In addition, we review the relevant literature and discuss the clinical management of colloid carcinoma derived from IPMN with prominent calcification, including the histopathological features. A 75-year-old man presented with a pancreatic tumor measuring 58 mm on the head of the pancreas that was incidentally detected by abdominal ultrasonography. Abdominal computed tomography and endosonography revealed a multilobular cystic lesion with a 17 mm mural nodule in the pancreatic head. Furthermore, prominent calcification was observed on part of the cyst wall. Magnetic resonance cholangiopancreatography showed a multilobular cyst in the branch duct lacking communication between the cystic lesion and the main pancreatic duct. Thus, the lesion was diagnosed as intraductal papillary mucinous carcinoma (IPMC) with a preoperative classification of T1N0M0 stage IA according to the 8th Union for International Cancer Control (UICC) guidelines, and the patient underwent conventional pancreatoduodenectomy. The resected specimen was microscopically found to contain colloid carcinoma, probably derived from IPMN. In addition, marked calcification was confirmed in the partition wall of the cystic mass. The postoperative course was uneventful, and no evidence of recurrence or metastasis was observed after 10 months of follow-up. We consider that colloid carcinoma derived from IPMN should be differentially diagnosed as a pancreatic multilobular cystic lesion with prominent calcification that shows no sign of systemic chronic pancreatitis.
Sections du résumé
BACKGROUND
BACKGROUND
Colloid carcinoma derived from intraductal papillary mucinous neoplasm (IPMN) of the pancreatic head with prominent calcification is exceedingly rare. Only a few studies about this entity have been reported in the literature. Therefore, its biological behavior, appropriate treatment modalities, and overall patient prognosis remain largely unclear. In this report, we present a case of a resected colloid carcinoma derived from IPMN with prominent calcification. In addition, we review the relevant literature and discuss the clinical management of colloid carcinoma derived from IPMN with prominent calcification, including the histopathological features.
CASE PRESENTATION
METHODS
A 75-year-old man presented with a pancreatic tumor measuring 58 mm on the head of the pancreas that was incidentally detected by abdominal ultrasonography. Abdominal computed tomography and endosonography revealed a multilobular cystic lesion with a 17 mm mural nodule in the pancreatic head. Furthermore, prominent calcification was observed on part of the cyst wall. Magnetic resonance cholangiopancreatography showed a multilobular cyst in the branch duct lacking communication between the cystic lesion and the main pancreatic duct. Thus, the lesion was diagnosed as intraductal papillary mucinous carcinoma (IPMC) with a preoperative classification of T1N0M0 stage IA according to the 8th Union for International Cancer Control (UICC) guidelines, and the patient underwent conventional pancreatoduodenectomy. The resected specimen was microscopically found to contain colloid carcinoma, probably derived from IPMN. In addition, marked calcification was confirmed in the partition wall of the cystic mass. The postoperative course was uneventful, and no evidence of recurrence or metastasis was observed after 10 months of follow-up.
CONCLUSIONS
CONCLUSIONS
We consider that colloid carcinoma derived from IPMN should be differentially diagnosed as a pancreatic multilobular cystic lesion with prominent calcification that shows no sign of systemic chronic pancreatitis.
Identifiants
pubmed: 34487254
doi: 10.1186/s40792-021-01286-5
pii: 10.1186/s40792-021-01286-5
pmc: PMC8421485
doi:
Types de publication
Journal Article
Langues
eng
Pagination
202Informations de copyright
© 2021. The Author(s).
Références
Clin Gastroenterol Hepatol. 2004 Jan;2(1):57-63
pubmed: 15017633
World J Gastroenterol. 2009 Mar 14;15(10):1273-5
pubmed: 19291831
J Pathol Bacteriol. 1968 Apr;95(2):547-9
pubmed: 4968111
Surg Today. 1998;28(12):1261-5
pubmed: 9872545
J Bone Miner Res. 2012 Aug;27(8):1619-22
pubmed: 22806925
Pathology. 2008 Dec;40(7):655-63
pubmed: 18985519
Int J Pancreatol. 1995 Jun;17(3):291-6
pubmed: 7642976
Pancreatology. 2006;6(6):626-34
pubmed: 17135772
Pancreatology. 2017 Sep - Oct;17(5):738-753
pubmed: 28735806
J Am Coll Surg. 2011 Aug;213(2):275-83
pubmed: 21601488
Gastroenterology. 1996 Jun;110(6):1909-18
pubmed: 8964418
Ann Surg. 2010 Mar;251(3):470-6
pubmed: 20142731
Case Rep Pancreat Cancer. 2016 Jun 01;2(1):40-45
pubmed: 30631814