EANM recommendations based on systematic analysis of small animal radionuclide imaging in inflammatory musculoskeletal diseases.
Inflammatory musculoskeletal disease
Molecular imaging
Positron emission tomography
Preclinical
Rheumatoid disease
Single photon emission computed tomography
Journal
EJNMMI research
ISSN: 2191-219X
Titre abrégé: EJNMMI Res
Pays: Germany
ID NLM: 101560946
Informations de publication
Date de publication:
06 Sep 2021
06 Sep 2021
Historique:
received:
16
07
2021
accepted:
02
08
2021
entrez:
6
9
2021
pubmed:
7
9
2021
medline:
7
9
2021
Statut:
epublish
Résumé
Inflammatory musculoskeletal diseases represent a group of chronic and disabling conditions that evolve from a complex interplay between genetic and environmental factors that cause perturbations in innate and adaptive immune responses. Understanding the pathogenesis of inflammatory musculoskeletal diseases is, to a large extent, derived from preclinical and basic research experiments. In vivo molecular imaging enables us to study molecular targets and to measure biochemical processes non-invasively and longitudinally, providing information on disease processes and potential therapeutic strategies, e.g. efficacy of novel therapeutic interventions, which is of complementary value next to ex vivo (post mortem) histopathological analysis and molecular assays. Remarkably, the large body of preclinical imaging studies in inflammatory musculoskeletal disease is in contrast with the limited reports on molecular imaging in clinical practice and clinical guidelines. Therefore, in this EANM-endorsed position paper, we performed a systematic review of the preclinical studies in inflammatory musculoskeletal diseases that involve radionuclide imaging, with a detailed description of the animal models used. From these reflections, we provide recommendations on what future studies in this field should encompass to facilitate a greater impact of radionuclide imaging techniques on the translation to clinical settings.
Identifiants
pubmed: 34487263
doi: 10.1186/s13550-021-00820-8
pii: 10.1186/s13550-021-00820-8
pmc: PMC8421483
doi:
Types de publication
Letter
Langues
eng
Pagination
85Informations de copyright
© 2021. The Author(s).
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