Microglia modulate hippocampal synaptic transmission and sleep duration along the light/dark cycle.
cx3cr1
electroencephalography
long-term potentiation
microglial depletion
miniature excitatory post-synaptic currents
sleep
spontaneous excitatory post-synaptic currents
Journal
Glia
ISSN: 1098-1136
Titre abrégé: Glia
Pays: United States
ID NLM: 8806785
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
revised:
27
08
2021
received:
02
03
2021
accepted:
27
08
2021
pubmed:
7
9
2021
medline:
11
3
2022
entrez:
6
9
2021
Statut:
ppublish
Résumé
Microglia, the brain's resident macrophages, actively contribute to the homeostasis of cerebral parenchyma by sensing neuronal activity and supporting synaptic remodeling and plasticity. While several studies demonstrated different roles for astrocytes in sleep, the contribution of microglia in the regulation of sleep/wake cycle and in the modulation of synaptic activity in the different day phases has not been deeply investigated. Using light as a zeitgeber cue, we studied the effects of microglial depletion with the colony stimulating factor-1 receptor antagonist PLX5622 on the sleep/wake cycle and on hippocampal synaptic transmission in male mice. Our data demonstrate that almost complete microglial depletion increases the duration of NREM sleep and reduces the hippocampal excitatory neurotransmission. The fractalkine receptor CX3CR1 plays a relevant role in these effects, because cx3cr1
Identifiants
pubmed: 34487590
doi: 10.1002/glia.24090
pmc: PMC9291950
doi:
Substances chimiques
CX3C Chemokine Receptor 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-105Informations de copyright
© 2021 The Authors. GLIA published by Wiley Periodicals LLC.
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