Untangling the web of 5-lipoxygenase-derived products from a molecular and structural perspective: The battle between pro- and anti-inflammatory lipid mediators.
Journal
Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
12
07
2021
revised:
29
08
2021
accepted:
01
09
2021
pubmed:
7
9
2021
medline:
7
1
2022
entrez:
6
9
2021
Statut:
ppublish
Résumé
Arachidonic acid (AA) is the precursor to leukotrienes (LT), potent mediators of the inflammatory response. In the 35 + years since cysteinyl-LTs were reported to mediate antigen-induced constriction of bronchi in tissue from asthma patients, numerous cellular responses evoked by the LTs, such as chemoattraction and G protein-coupled receptor (GPCR) activation, have been elucidated and revealed a potential for 5-lipoxygenase (5-LOX) as a promising drug target that goes beyond asthma. We describe herein early work identifying 5-LOX as the key enzyme that initiates LT biosynthesis and the discovery of its membrane-embedded helper protein required to execute the two-step reaction that transforms AA to the progenitor leukotriene A
Identifiants
pubmed: 34487716
pii: S0006-2952(21)00375-0
doi: 10.1016/j.bcp.2021.114759
pmc: PMC8865081
mid: NIHMS1740068
pii:
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Lipids
0
Arachidonate 5-Lipoxygenase
EC 1.13.11.34
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
114759Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL107887
Pays : United States
Organisme : NIGMS NIH HHS
ID : R15 GM143724
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier Inc.
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