Therapeutic potential of marine peptides in glioblastoma: Mechanistic insights.
Angiogenesis
Apoptosis
Cell cycle arrest
Marine peptides
Metastasis
Mitosis
Journal
Cellular signalling
ISSN: 1873-3913
Titre abrégé: Cell Signal
Pays: England
ID NLM: 8904683
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
24
08
2021
revised:
01
09
2021
accepted:
01
09
2021
pubmed:
7
9
2021
medline:
1
4
2022
entrez:
6
9
2021
Statut:
ppublish
Résumé
Glioblastoma multiforme (GBM) is the most common primary malignant brain tumor in humans. It is characterized by excessive cell growth and accelerated intrusion of normal brain tissue along with a poor prognosis. The current standard of treatment, including surgical removal, radiation therapy, and chemotherapy, is largely ineffective, with high mortality and recurrence rates. As a result, traditional approaches have evolved to include new alternative remedies, such as natural compounds. Aquatic species provide a rich supply of possible drugs. The physiological effects of marine peptides in glioblastoma are mediated by a range of pathways, including apoptosis, microtubule balance disturbances, suppression of angiogenesis, cell migration/invasion, and cell viability; autophagy and metabolic enzymes downregulation. Herein, we address the efficacy of marine peptides as putative safe therapeutic agents for glioblastoma coupled with detail molecular mechanisms.
Identifiants
pubmed: 34487816
pii: S0898-6568(21)00231-X
doi: 10.1016/j.cellsig.2021.110142
pii:
doi:
Substances chimiques
Peptides
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
110142Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES010563
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES010563
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.