Cellular reprogramming and epigenetic rejuvenation.
Ageing
Cellular reprogramming
Epigenetic age
Epigenetic clocks
Rejuvenation
Reprogramming-induced rejuvenation
Transient reprogramming
Journal
Clinical epigenetics
ISSN: 1868-7083
Titre abrégé: Clin Epigenetics
Pays: Germany
ID NLM: 101516977
Informations de publication
Date de publication:
06 09 2021
06 09 2021
Historique:
received:
04
06
2021
accepted:
02
08
2021
entrez:
7
9
2021
pubmed:
8
9
2021
medline:
10
2
2022
Statut:
epublish
Résumé
Ageing is an inevitable condition that afflicts all humans. Recent achievements, such as the generation of induced pluripotent stem cells, have delivered preliminary evidence that slowing down and reversing the ageing process might be possible. However, these techniques usually involve complete dedifferentiation, i.e. somatic cell identity is lost as cells are converted to a pluripotent state. Separating the rejuvenative properties of reprogramming from dedifferentiation is a promising prospect, termed epigenetic rejuvenation. Reprogramming-induced rejuvenation strategies currently involve using Yamanaka factors (typically transiently expressed to prevent full dedifferentiation) and are promising candidates to safely reduce biological age. Here, we review the development and potential of reprogramming-induced rejuvenation as an anti-ageing strategy.
Identifiants
pubmed: 34488874
doi: 10.1186/s13148-021-01158-7
pii: 10.1186/s13148-021-01158-7
pmc: PMC8419998
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
170Subventions
Organisme : Medical Research Council
ID : MR/S034676/1
Pays : United Kingdom
Informations de copyright
© 2021. The Author(s).
Références
J Infect Dis. 2015 Nov 15;212(10):1563-73
pubmed: 25969563
Nat Commun. 2015 May 19;6:7131
pubmed: 25988592
Science. 2008 Aug 1;321(5889):699-702
pubmed: 18276851
Science. 2012 Nov 23;338(6110):1080-4
pubmed: 23087000
Nat Commun. 2020 Mar 24;11(1):1545
pubmed: 32210226
Aging Cell. 2019 Feb;18(1):e12877
pubmed: 30450724
Stem Cells. 2011 Jun;29(6):992-1000
pubmed: 21563275
J Gerontol. 1988 Mar;43(2):B40-2
pubmed: 3346517
Hum Mol Genet. 2016 Jan 1;25(1):191-201
pubmed: 26546615
Cell Rep. 2014 Dec 11;9(5):1603-1609
pubmed: 25464850
Nat Rev Genet. 2018 Jun;19(6):371-384
pubmed: 29643443
Nat Cell Biol. 2020 May;22(5):513-515
pubmed: 32367045
Aging (Albany NY). 2017 Apr;9(4):1143-1152
pubmed: 28377537
Sci Signal. 2009 Nov 24;2(98):ra75
pubmed: 19934433
EBioMedicine. 2017 Jul;21:21-28
pubmed: 28416161
Nature. 2020 Dec;588(7836):124-129
pubmed: 33268865
Genome Biol. 2017 Mar 28;18(1):57
pubmed: 28351423
Cell. 2013 Jun 6;153(6):1194-217
pubmed: 23746838
Proc Natl Acad Sci U S A. 2001 Jan 30;98(3):1077-82
pubmed: 11158597
Proc Natl Acad Sci U S A. 2014 Oct 28;111(43):15538-43
pubmed: 25313081
Exp Mol Med. 2020 Feb;52(2):213-226
pubmed: 32080339
Genome Biol. 2013 Jul 26;14(7):R75
pubmed: 23889843
Nutrition. 1989 May-Jun;5(3):155-71; discussion 172
pubmed: 2520283
Front Cell Dev Biol. 2015 Feb 02;3:2
pubmed: 25699255
Nature. 2011 Nov 02;479(7372):232-6
pubmed: 22048312
Cell. 2012 Jan 20;148(1-2):46-57
pubmed: 22265401
Cell. 2006 Aug 25;126(4):663-76
pubmed: 16904174
Cell Res. 2016 Jan;26(1):34-45
pubmed: 26704449
Nature. 2009 Jul 16;460(7253):392-5
pubmed: 19587680
Nat Genet. 2009 Sep;41(9):968-76
pubmed: 19668214
Lancet Diabetes Endocrinol. 2019 Sep;7(9):673-683
pubmed: 31303390
Clin Epigenetics. 2020 Jul 13;12(1):105
pubmed: 32660606
Curr Opin Cell Biol. 2012 Dec;24(6):744-56
pubmed: 23146768
Aging (Albany NY). 2016 Jul;8(7):1485-512
pubmed: 27479945
Cell. 2014 Feb 13;156(4):663-77
pubmed: 24529372
J Gerontol A Biol Sci Med Sci. 2011 Feb;66(2):191-201
pubmed: 20974732
Geroscience. 2021 Apr;43(2):463-485
pubmed: 33825176
Nat Rev Mol Cell Biol. 2020 Mar;21(3):137-150
pubmed: 32020082
Science. 2000 Apr 28;288(5466):665-9
pubmed: 10784448
Stem Cell Res. 2009 May;2(3):198-210
pubmed: 19393593
Nat Genet. 2000 Nov;26(3):272-3
pubmed: 11062462
Nature. 1981 Jul 9;292(5819):154-6
pubmed: 7242681
Cell Metab. 2008 Aug;8(2):157-68
pubmed: 18599363
Science. 2014 May 9;344(6184):649-52
pubmed: 24797481
Curr Biol. 2008 Jun 24;18(12):890-4
pubmed: 18501604
Biol Psychiatry. 2020 Aug 1;88(3):224-235
pubmed: 32199607
Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12172-9
pubmed: 23812749
Cell. 2013 May 9;153(4):828-39
pubmed: 23663781
Nature. 2000 Sep 21;407(6802):318-9
pubmed: 11014179
Nat Biotechnol. 2008 Nov;26(11):1276-84
pubmed: 18931654
Cell. 2019 Mar 21;177(1):200-220
pubmed: 30901541
EMBO Rep. 2014 Mar;15(3):244-53
pubmed: 24531722
Nat Med. 2015 Aug;21(8):932-7
pubmed: 26147761
Nature. 2003 Jan 9;421(6919):182-7
pubmed: 12483226
Cell Stem Cell. 2012 Jan 6;10(1):96-103
pubmed: 22226359
Aging Cell. 2015 Aug;14(4):644-58
pubmed: 25754370
Physiol Genomics. 2003 Jul 07;14(2):149-59
pubmed: 12783983
NPJ Regen Med. 2020 Jul 31;5:14
pubmed: 32821434
Trends Genet. 2008 Dec;24(12):604-12
pubmed: 18992957
Nat Commun. 2015 Oct 22;6:8570
pubmed: 26490707
Aging Cell. 2013 Apr;12(2):324-6
pubmed: 23311345
Nature. 1990 Aug 30;346(6287):866-8
pubmed: 2392154
Nature. 2008 Feb 28;451(7182):1069-75
pubmed: 18305538
Genes Dev. 2011 Nov 1;25(21):2248-53
pubmed: 22056670
Science. 2003 Jan 24;299(5606):572-4
pubmed: 12543978
Science. 2007 Aug 10;317(5839):807-10
pubmed: 17690295
Biochem Biophys Res Commun. 2020 May 7;525(3):563-569
pubmed: 32115145
Mutat Res. 1991 Jan;256(1):45-8
pubmed: 1944386
Genome Res. 2017 Apr;27(4):545-552
pubmed: 28302734
Cell Stem Cell. 2011 Jan 7;8(1):96-105
pubmed: 21211784
J Embryol Exp Morphol. 1962 Dec;10:622-40
pubmed: 13951335
Rejuvenation Res. 2010 Feb;13(1):65-74
pubmed: 20230280
Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12426-31
pubmed: 25097266
J Biosci. 2010 Jun;35(2):315-9
pubmed: 20689186
Nature. 2013 Jan 17;493(7432):338-45
pubmed: 23325216
Nature. 1997 Feb 27;385(6619):810-3
pubmed: 9039911
Nat Med. 2014 Jun;20(6):659-63
pubmed: 24793238
Cell. 2016 Dec 15;167(7):1719-1733.e12
pubmed: 27984723
Genome Biol. 2019 Aug 14;20(1):146
pubmed: 31409373
Aging Cell. 2011 Oct;10(5):868-78
pubmed: 21668623
Cell. 2005 Feb 25;120(4):437-47
pubmed: 15734677
Science. 2013 Aug 9;341(6146):651-4
pubmed: 23868920
PLoS One. 2020 Aug 4;15(8):e0237006
pubmed: 32750074
Cell Stem Cell. 2013 Dec 5;13(6):691-705
pubmed: 24315443
Cell. 2015 Jan 29;160(3):477-88
pubmed: 25619689
Nucleic Acids Res. 2018 Jan 4;46(D1):D1083-D1090
pubmed: 29121237
Bioinformatics. 2009 Apr 1;25(7):875-81
pubmed: 19189975
Genome Biol. 2015 Jan 30;16:25
pubmed: 25633388
Aging (Albany NY). 2016 Sep 28;8(9):1844-1865
pubmed: 27690265
Aging (Albany NY). 2019 Jan 21;11(2):303-327
pubmed: 30669119
Cell Cycle. 2011 Dec 15;10(24):4230-6
pubmed: 22107964
Cell Stem Cell. 2009 Feb 6;4(2):141-54
pubmed: 19200803
PLoS One. 2010 Nov 23;5(11):e14095
pubmed: 21124794
Genome Biol. 2018 Dec 20;19(1):221
pubmed: 30567591
Cell Rep. 2017 May 23;19(8):1503-1511
pubmed: 28538171
Stem Cells Dev. 2014 Jun 15;23(12):1285-300
pubmed: 24524728
Nature. 2004 Jun 24;429(6994):883-91
pubmed: 15190254
Nat Commun. 2016 Jan 08;7:10286
pubmed: 26743714
J Clin Invest. 2013 Aug;123(8):3272-91
pubmed: 23863708
Proc Natl Acad Sci U S A. 1998 May 12;95(10):5607-10
pubmed: 9576930
Gerontology. 2017;63(5):417-425
pubmed: 27820924
Proc Natl Acad Sci U S A. 1981 Dec;78(12):7634-8
pubmed: 6950406
Nature. 1958 Jul 5;182(4627):64-5
pubmed: 13566187
Sci Rep. 2014 Apr 25;4:4789
pubmed: 24763337
Cell. 2008 Apr 18;133(2):250-64
pubmed: 18423197
Nat Commun. 2016 Jul 26;7:12359
pubmed: 27459299
Nat Rev Mol Cell Biol. 2018 Sep;19(9):594-610
pubmed: 29858605
Nat Rev Mol Cell Biol. 2016 Mar;17(3):183-93
pubmed: 26883003
Nat Cell Biol. 2019 Jan;21(1):32-43
pubmed: 30602763
Stem Cell Res Ther. 2019 Nov 21;10(1):341
pubmed: 31753034
Nature. 2011 Aug 31;477(7362):90-4
pubmed: 21886162
Nature. 2005 Feb 17;433(7027):760-4
pubmed: 15716955
Nature. 2013 Oct 17;502(7471):340-5
pubmed: 24025773
Nature. 1999 May 27;399(6734):316-7
pubmed: 10360570
Cell. 2013 Jan 17;152(1-2):25-38
pubmed: 23273993
Aging (Albany NY). 2018 Jul 26;10(7):1758-1775
pubmed: 30048243
Curr Opin Genet Dev. 2010 Apr;20(2):190-6
pubmed: 20176474
J Biosci. 2019 Sep;44(4):
pubmed: 31502583
Genome Biol. 2013;14(10):R115
pubmed: 24138928
Nature. 2011 Apr 14;472(7342):221-5
pubmed: 21346760
Sci Adv. 2021 Jun 25;7(26):
pubmed: 34172448
PLoS Biol. 2004 Dec;2(12):e427
pubmed: 15562319
Aging Cell. 2016 Dec;15(6):1074-1081
pubmed: 27561685
J Nutr. 1986 Apr;116(4):641-54
pubmed: 3958810
Clin Epigenetics. 2019 Dec 4;11(1):183
pubmed: 31801625
Genes Cells. 2012 May;17(5):337-43
pubmed: 22487104
Epigenetics Chromatin. 2018 Dec 20;11(1):73
pubmed: 30572909
Nature. 2016 Feb 11;530(7589):184-9
pubmed: 26840489
Inflamm Regen. 2020 Nov 5;40(1):29
pubmed: 33292805
Science. 2014 May 9;344(6184):630-4
pubmed: 24797482
Nat Cell Biol. 2003 Jun;5(6):535-8
pubmed: 12738962
Nature. 1990 May 31;345(6274):458-60
pubmed: 2342578