Annelid genomes: Enchytraeus crypticus, a soil model for the innate (and primed) immune system.
Journal
Lab animal
ISSN: 1548-4475
Titre abrégé: Lab Anim (NY)
Pays: United States
ID NLM: 0417737
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
20
02
2021
accepted:
26
07
2021
pubmed:
8
9
2021
medline:
28
9
2021
entrez:
7
9
2021
Statut:
ppublish
Résumé
Enchytraeids (Annelida) are soil invertebrates with worldwide distribution that have served as ecotoxicology models for over 20 years. We present the first high-quality reference genome of Enchytraeus crypticus, assembled from a combination of Pacific Bioscience single-molecule real-time and Illumina sequencing platforms as a 525.2 Mbp genome (910 gapless scaffolds and 18,452 genes). We highlight isopenicillin, acquired by horizontal gene transfer and conferring antibiotic function. Significant gene family expansions associated with regeneration (long interspersed nuclear elements), the innate immune system (tripartite motif-containing protein) and response to stress (cytochrome P450) were identified. The ACE (Angiotensin-converting enzyme) - a homolog of ACE2, which is involved in the coronavirus SARS-CoV-2 cell entry - is also present in E. crypticus. There is an obvious potential of using E. crypticus as a model to study interactions between regeneration, the innate immune system and aging-dependent decline.
Identifiants
pubmed: 34489599
doi: 10.1038/s41684-021-00831-x
pii: 10.1038/s41684-021-00831-x
pmc: PMC8460440
doi:
Substances chimiques
Soil
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
285-294Informations de copyright
© 2021. The Author(s).
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