Amphibian (
Age Factors
Amphibian Proteins
/ metabolism
Animals
DNA Virus Infections
/ immunology
Disease Susceptibility
Female
Host-Pathogen Interactions
Interferons
/ metabolism
Intestines
/ embryology
Larva
/ immunology
Male
Myeloid Cells
/ immunology
Ranavirus
/ immunology
Viral Load
Xenopus laevis
/ embryology
amphibian
interferons
intestine
myeloid cells
ranavirus
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
06
07
2021
accepted:
05
08
2021
entrez:
7
9
2021
pubmed:
8
9
2021
medline:
25
12
2021
Statut:
epublish
Résumé
The global amphibian declines are compounded by ranavirus infections such as Frog Virus 3 (FV3), and amphibian tadpoles more frequently succumb to these pathogens than adult animals. Amphibian gastrointestinal tracts represent a major route of ranavirus entry, and viral pathogenesis often leads to hemorrhaging and necrosis within this tissue. Alas, the differences between tadpole and adult amphibian immune responses to intestinal ranavirus infections remain poorly defined. As interferon (IFN) cytokine responses represent a cornerstone of vertebrate antiviral immunity, it is pertinent that the tadpoles and adults of the anuran
Identifiants
pubmed: 34489981
doi: 10.3389/fimmu.2021.737403
pmc: PMC8418544
doi:
Substances chimiques
Amphibian Proteins
0
Interferons
9008-11-1
Types de publication
Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
737403Informations de copyright
Copyright © 2021 Hauser, Singer, Hossainey, Moore, Wendel, Yaparla, Kalia and Grayfer.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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