Parkinson's Disease: A Nanotheranostic Approach Targeting Alpha-Synuclein Aggregation.
Parkinson’s disease
alpha-synuclein
diagnostic
magnetic resonance imaging
nanoparticle
nanotechnology
nanotheranostic
therapeutic
Journal
Frontiers in cell and developmental biology
ISSN: 2296-634X
Titre abrégé: Front Cell Dev Biol
Pays: Switzerland
ID NLM: 101630250
Informations de publication
Date de publication:
2021
2021
Historique:
received:
10
05
2021
accepted:
07
07
2021
entrez:
7
9
2021
pubmed:
8
9
2021
medline:
8
9
2021
Statut:
epublish
Résumé
Parkinson's disease (PD) is one of the most common neurodegenerative disorders that is implicated in aging populations. As numerous developed nations are experiencing progressively aging populations today, there is a heightened propensity for the occurrence of PD cases. Alpha-synuclein (α-syn) aggregation has been considered to be the pivotal mechanism leading to PD pathogenesis. Thus, early diagnostic and therapeutic strategies targeting the misfolded α-syn protein can potentially improve the prognosis of PD. With rapid advancements in nanotechnology in the last decade, effective solutions to various neurodegenerative and oncological diseases have been suggested. This review will explore the current innovations in nanotechnology that target the α-syn aggregation pathway, and reinstate the promise they hold as effective early diagnostic and therapeutic solutions to PD.
Identifiants
pubmed: 34490255
doi: 10.3389/fcell.2021.707441
pmc: PMC8418352
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
707441Informations de copyright
Copyright © 2021 Zoey, Palanivel, Padmanabhan and Gulyás.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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