Activity-dependent regulation of mitochondrial motility in developing cortical dendrites.
calcium signaling
in vivo imaging
intracellular transport
mouse
neuroscience
synaptic transmission
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
07 09 2021
07 09 2021
Historique:
received:
13
08
2020
accepted:
24
08
2021
entrez:
7
9
2021
pubmed:
8
9
2021
medline:
3
11
2021
Statut:
epublish
Résumé
Developing neurons form synapses at a high rate. Synaptic transmission is very energy-demanding and likely requires ATP production by mitochondria nearby. Mitochondria might be targeted to active synapses in young dendrites, but whether such motility regulation mechanisms exist is unclear. We investigated the relationship between mitochondrial motility and neuronal activity in the primary visual cortex of young mice in vivo and in slice cultures. During the first 2 postnatal weeks, mitochondrial motility decreases while the frequency of neuronal activity increases. Global calcium transients do not affect mitochondrial motility. However, individual synaptic transmission events precede local mitochondrial arrest. Pharmacological stimulation of synaptic vesicle release, but not focal glutamate application alone, stops mitochondria, suggesting that an unidentified factor co-released with glutamate is required for mitochondrial arrest. A computational model of synaptic transmission-mediated mitochondrial arrest shows that the developmental increase in synapse number and transmission frequency can contribute substantially to the age-dependent decrease of mitochondrial motility.
Identifiants
pubmed: 34491202
doi: 10.7554/eLife.62091
pii: 62091
pmc: PMC8423438
doi:
pii:
Substances chimiques
Glutamic Acid
3KX376GY7L
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Silva et al.
Déclaration de conflit d'intérêts
CS, AY, MF, MV, CL None, Mv none
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