Episome partitioning and symmetric cell divisions: Quantifying the role of random events in the persistence of HPV infections.
Journal
PLoS computational biology
ISSN: 1553-7358
Titre abrégé: PLoS Comput Biol
Pays: United States
ID NLM: 101238922
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
12
04
2021
accepted:
16
08
2021
revised:
17
09
2021
pubmed:
8
9
2021
medline:
15
12
2021
entrez:
7
9
2021
Statut:
epublish
Résumé
Human Papillomaviruses (HPV) are one of the most prevalent sexually transmitted infections (STI) and the most oncogenic viruses known to humans. The vast majority of HPV infections clear in less than 3 years, but the underlying mechanisms, especially the involvement of the immune response, are still poorly known. Building on earlier work stressing the importance of randomness in the type of cell divisions in the clearance of HPV infection, we develop a stochastic mathematical model of HPV dynamics that combines the previous aspect with an explicit description of the intracellular level. We show that the random partitioning of virus episomes upon stem cell division and the occurrence of symmetric divisions dramatically affect viral persistence. These results call for more detailed within-host studies to better understand the relative importance of stochasticity and immunity in HPV infection clearance.
Identifiants
pubmed: 34491986
doi: 10.1371/journal.pcbi.1009352
pii: PCOMPBIOL-D-21-00650
pmc: PMC8448377
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1009352Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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