Neuroimmune interactions and immunoengineering strategies in peripheral nerve repair.
Immunoengineering
Immunomodulation
Macrophages
Peripheral nerve injury
Regeneration
Journal
Progress in neurobiology
ISSN: 1873-5118
Titre abrégé: Prog Neurobiol
Pays: England
ID NLM: 0370121
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
received:
29
04
2021
revised:
11
08
2021
accepted:
02
09
2021
pubmed:
8
9
2021
medline:
22
3
2022
entrez:
7
9
2021
Statut:
ppublish
Résumé
Peripheral nerve injuries result in disrupted cellular communication between the central nervous system and somatic distal end targets. The peripheral nervous system is capable of independent and extensive regeneration; however, meaningful target muscle reinnervation and functional recovery remain limited and may result in chronic neuropathic pain and diminished quality of life. Macrophages, the primary innate immune cells of the body, are critical contributors to regeneration of the injured peripheral nervous system. However, in some clinical scenarios, macrophages may fail to provide adequate support with optimal timing, duration, and location. Here, we review the history of immunosuppressive and immunomodulatory strategies to treat nerve injuries. Thereafter, we enumerate the ways in which macrophages contribute to successful nerve regeneration. We argue that implementing macrophage-based immunomodulatory therapies is a promising treatment strategy for nerve injuries across a wide range of clinical presentations.
Identifiants
pubmed: 34492307
pii: S0301-0082(21)00186-6
doi: 10.1016/j.pneurobio.2021.102172
pmc: PMC8712351
mid: NIHMS1741444
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102172Subventions
Organisme : NINDS NIH HHS
ID : R03 NS116301
Pays : United States
Organisme : NINDS NIH HHS
ID : R43 NS108869
Pays : United States
Organisme : BLRD VA
ID : I01 BX003748
Pays : United States
Organisme : NINDS NIH HHS
ID : T32 NS043126
Pays : United States
Organisme : NINDS NIH HHS
ID : F32 NS116205
Pays : United States
Organisme : NINDS NIH HHS
ID : R44 NS108869
Pays : United States
Organisme : NIBIB NIH HHS
ID : T32 EB005583
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Ltd. All rights reserved.
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