Multiple drug resistance in hookworms infecting greyhound dogs in the USA.
Ancylostoma caninum, hookworms
Deep-amplicon
Greyhounds
Multiple-drug resistance (MDR)
Journal
International journal for parasitology. Drugs and drug resistance
ISSN: 2211-3207
Titre abrégé: Int J Parasitol Drugs Drug Resist
Pays: Netherlands
ID NLM: 101576715
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
24
04
2021
revised:
15
08
2021
accepted:
19
08
2021
pubmed:
8
9
2021
medline:
7
1
2022
entrez:
7
9
2021
Statut:
ppublish
Résumé
Ancylostoma caninum is the most prevalent nematode parasite of dogs. We confirmed multiple-drug resistance (MDR) in several A. caninum isolates to all anthelmintic drug classes approved for the treatment of hookworms in dogs in the USA. Cases of MDR hookworms appear to be highly overrepresented in greyhounds. The aims of this study were to evaluate the drug-resistant phenotypes and genotypes of the A. caninum infecting greyhounds. Fecal samples from greyhounds of the USA were acquired from two greyhound adoption kennels, one active greyhound racing kennel, and three veterinary practices. Fecal egg counts (FECs) were performed on fecal samples from 219 greyhounds, and despite treatment with anthelmintics, the mean FEC was 822.4 eggs per gram (EPG). Resistance to benzimidazoles and macrocyclic lactones were measured using the egg hatch assay (EHA) and the larval development assay (LDA), respectively. We performed 23 EHA and 22 LDA on either individual or pooled feces, representing 54 animals. Mean and median IC
Identifiants
pubmed: 34492564
pii: S2211-3207(21)00041-5
doi: 10.1016/j.ijpddr.2021.08.005
pmc: PMC8426179
pii:
doi:
Substances chimiques
Anthelmintics
0
Pyrantel
4QIH0N49E7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
107-117Informations de copyright
Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.