Clean and folded: Production of active, high quality recombinant human interferon-λ1.
Cation exchange chromatography
Immobilized metal affinity chromatography
Interferon-lambda
Refolding
Journal
Process biochemistry (Barking, London, England)
ISSN: 1359-5113
Titre abrégé: Process Biochem
Pays: England
ID NLM: 9211419
Informations de publication
Date de publication:
Dec 2021
Dec 2021
Historique:
received:
21
02
2021
revised:
30
08
2021
accepted:
31
08
2021
entrez:
8
9
2021
pubmed:
9
9
2021
medline:
9
9
2021
Statut:
ppublish
Résumé
Type III interferons exhibit antiviral activity against influenza viruses, coronaviruses, rotaviruses, and others. In addition, this type of interferon theoretically has therapeutic advantages, in comparison with type I interferons, due to its ability to activate a narrower group of genes in a relatively small group of target cells. Hence, it can elicit more targeted antiviral or immunomodulatory responses. Obtaining biologically-active interferon lambda (hIFN-λ
Identifiants
pubmed: 34493923
doi: 10.1016/j.procbio.2021.08.029
pii: S1359-5113(21)00270-1
pmc: PMC8411590
doi:
Types de publication
Journal Article
Langues
eng
Pagination
32-39Informations de copyright
© 2021 Elsevier Ltd. All rights reserved.
Déclaration de conflit d'intérêts
The authors report no declarations of interest.
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