An IDH-independent mechanism of DNA hypermethylation upon VHL inactivation in cancer.
DNA methylation
HIF1A
VHL
hypoxia
kidney cancer
Journal
Epigenetics
ISSN: 1559-2308
Titre abrégé: Epigenetics
Pays: United States
ID NLM: 101265293
Informations de publication
Date de publication:
08 2022
08 2022
Historique:
pubmed:
9
9
2021
medline:
30
8
2022
entrez:
8
9
2021
Statut:
ppublish
Résumé
Hypermethylation of tumour suppressors and other aberrations of DNA methylation in tumours play a significant role in cancer progression. DNA methylation can be affected by various environmental conditions, including hypoxia. The response to hypoxia is mainly achieved through activation of the transcriptional program associated with HIF1A transcription factor. Inactivation of Von Hippel-Lindau Tumour Suppressor gene (
Identifiants
pubmed: 34494499
doi: 10.1080/15592294.2021.1971372
pmc: PMC9423849
doi:
Substances chimiques
DNA
9007-49-2
Alcohol Oxidoreductases
EC 1.1.-
Isocitrate Dehydrogenase
EC 1.1.1.41
L2HGDH protein, human
EC 1.1.99.2
Von Hippel-Lindau Tumor Suppressor Protein
EC 2.3.2.27
VHL protein, human
EC 6.3.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
894-905Références
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