Pharmacokinetic and pharmacodynamic properties of aerosolized ("vaped") THC in adolescent male and female rats.

Animals Dronabinol / pharmacology Female Hallucinogens Hypothermia Male Rats Rats, Wistar Vaping
Anxiety Blood Brain E-cigarette Inhalation Locomotion Pharmacodynamics Pharmacokinetics THC Vapor

Journal

Psychopharmacology
ISSN: 1432-2072
Titre abrégé: Psychopharmacology (Berl)
Pays: Germany
ID NLM: 7608025

Informations de publication

Date de publication:
Dec 2021
Historique:
received: 02 06 2021
accepted: 23 08 2021
pubmed: 9 9 2021
medline: 15 12 2021
entrez: 8 9 2021
Statut: ppublish

Résumé

Adolescent exposure to ∆ We investigated the pharmacokinetics and pharmacodynamics of aerosolized THC (30 min inhalation exposure, 25 or 100 mg/ml) in adolescent Wistar rats of both sexes. Liquid chromatography/mass spectrometry analysis of THC and its major metabolites was conducted on blood plasma and brain tissue at 5, 30, 60, and 120 min following a 30-min aerosol dosing session. Effects on activity in a novel environment for 120 min after aerosol, and temperature, were measured in separate rats. We found sex-dependent differences in the pharmacokinetics of THC and its active (11-OH-THC) and inactive (11-COOH-THC) metabolites in the blood and brain, along with dose- and sex-dependent effects on anxiety-like and exploratory behaviors; namely, greater 11-OH-THC levels accompanied by greater behavioral effects in females at the low dose but similar hypothermic effects in both sexes at the high dose. These results provide a benchmark for dosing adolescent rats with aerosolized (or "vaped") THC, which could facilitate adoption by other labs of this potentially human-relevant THC exposure model to understand cannabis effects on the developing brain.

Identifiants

DOI: 10.1007/s00213-021-05976-8 PMID: 34495367 PMC: PMC8665923
pubmed: 34495367
doi: 10.1007/s00213-021-05976-8
pii: 10.1007/s00213-021-05976-8
pmc: PMC8665923
mid: NIHMS1749825
doi:

Substances chimiques

Hallucinogens 0
Dronabinol 7J8897W37S

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3595-3605

Subventions

Organisme : NIDA NIH HHS
ID : DP1 DA031387
Pays : United States
Organisme : NIDA NIH HHS
ID : R01 DA051831
Pays : United States
Organisme : NIDA NIH HHS
ID : DA051831
Pays : United States
Organisme : NIDA NIH HHS
ID : P50 DA044118
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.

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Auteurs

C M Ruiz (CM)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA.

A Torrens (A)

Department of Anatomy & Neurobiology, University of California Irvine, 1244 Gillespie Hall, Irvine, CA, 92697, USA.

V Lallai (V)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA.

E Castillo (E)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA.

L Manca (L)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA.

M X Martinez (MX)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA.

D N Justeson (DN)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA.

C D Fowler (CD)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA.

D Piomelli (D)

Department of Anatomy & Neurobiology, University of California Irvine, 1244 Gillespie Hall, Irvine, CA, 92697, USA.

S V Mahler (SV)

Department of Neurobiology & Behavior, University of California Irvine, 2205 McGaugh Hall, Irvine, CA, 92697, USA. mahlers@uci.edu.

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