Do postoperative antibiotics influence one-year peri-implant crestal bone remodelling and morbidity? A double-blinded randomized clinical trial.
clinical research
clinical trials
drug delivery
patient-centred outcomes
pharmacology
wound healing
Journal
Clinical oral implants research
ISSN: 1600-0501
Titre abrégé: Clin Oral Implants Res
Pays: Denmark
ID NLM: 9105713
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
revised:
25
06
2021
received:
16
04
2021
accepted:
20
07
2021
pubmed:
9
9
2021
medline:
16
11
2021
entrez:
8
9
2021
Statut:
ppublish
Résumé
The primary objective of this study was to assess whether giving postoperative antibiotics to healthy patients after straightforward platform-switched implant placement would influence peri-implant crestal bone levels and postoperative morbidity after 1 year. Thirty-eight healthy individuals were recruited in this pilot, randomized, double-blinded, placebo-controlled clinical trial. The intervention group (n = 18) received two grams of amoxicillin one hour before implant placement followed by a 7 days postoperative regimen (500 mg tid). The control group (n = 20) took the same preoperative dose of amoxicillin and an identical placebo postoperatively. Mesial and distal peri-implant crestal bone levels were measured at baseline, four months and one year later with standardized periapical radiographs. Postoperative pain severity was assessed through self-administered questionnaires for 7 days. Surgery-associated morbidities were evaluated after one, three, 16 weeks and 1 year. Descriptive and bivariate analyses were used. Thirty-seven participants completed the trial. At the one-year follow-up, the mean combined peri-implant crestal bone changes for the intervention (n = 18) and control (n = 19) groups were - 0.44 ± 0.41 mm and - 0.27 ± 0.56 mm, respectively. The difference between the groups (intervention-control) for mean combined crestal bone level changes was not statistically significant. There were no significant differences in surgery-associated morbidities between the intervention and control groups. The one-year implant survival rate was 100% in both groups. Study results suggest that a routine postoperative antibiotic regimen for healthy patients undergoing straightforward platform-switched implant placement might not be necessary to prevent postoperative peri-implant bone loss and complications.
Identifiants
pubmed: 34496085
doi: 10.1111/clr.13832
pmc: PMC9293101
doi:
Substances chimiques
Anti-Bacterial Agents
0
Dental Implants
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Pagination
1318-1327Subventions
Organisme : Université de Montréal
Informations de copyright
© 2021 The Authors. Clinical Oral Implants Research published by John Wiley & Sons Ltd.
Références
Oral Microbiol Immunol. 1987 Dec;2(4):145-51
pubmed: 3507627
Int J Oral Maxillofac Surg. 2014 Apr;43(4):487-90
pubmed: 24183737
Clin Oral Implants Res. 2021 Nov;32(11):1318-1327
pubmed: 34496085
Int J Oral Maxillofac Implants. 2017 Jan/Feb;32(1):e9-e24
pubmed: 28095526
Int J Oral Maxillofac Implants. 1986 Summer;1(1):11-25
pubmed: 3527955
J Prosthet Dent. 1989 Nov;62(5):567-72
pubmed: 2691661
Int J Oral Maxillofac Implants. 2006 Nov-Dec;21(6):943-50
pubmed: 17190305
J Clin Periodontol. 2000 Feb;27(2):79-86
pubmed: 10703651
Int J Oral Maxillofac Implants. 2005 Jan-Feb;20(1):115-7
pubmed: 15747682
Cochrane Database Syst Rev. 2013 Jul 31;(7):CD004152
pubmed: 23904048
Clin Implant Dent Relat Res. 2017 Jun;19(3):404-412
pubmed: 28185409
Br Dent J. 2020 Jun;228(12):943-951
pubmed: 32591710
J Oral Rehabil. 2014 Jun;41(6):443-76
pubmed: 24612346
Clin Oral Implants Res. 2014 Feb;25(2):185-93
pubmed: 23347336
J Clin Periodontol. 2016 Dec;43(12):1151-1159
pubmed: 27554366
Ann Periodontol. 2000 Dec;5(1):137-51
pubmed: 11885173
J Oral Maxillofac Surg. 1997 Dec;55(12 Suppl 5):25-30
pubmed: 9393423
J Dent Res. 2016 Aug;95(9):995-1002
pubmed: 27146701
Eur J Oral Implantol. 2015 Summer;8(2):143-9
pubmed: 26021225
Clin Oral Implants Res. 2015 Sep;26 Suppl 11:1-14
pubmed: 26080862
Clin Oral Implants Res. 2003 Feb;14(1):115-8
pubmed: 12562373
J Prosthodont Res. 2015 Jul;59(3):194-8
pubmed: 26077378
Periodontol 2000. 2013 Jun;62(1):256-70
pubmed: 23574471
J Prosthet Dent. 2016 Oct;116(4):501-506.e5
pubmed: 27422232
J Oral Implantol. 2011 Dec;37(6):691-6
pubmed: 20553148
Clin Oral Implants Res. 2014 Feb;25(2):252-9
pubmed: 23406290
PLoS One. 2020 Aug 18;15(8):e0236981
pubmed: 32810135
J Clin Periodontol. 2019 Mar;46(3):382-395
pubmed: 30729548