Exosomes as mediators of intercellular crosstalk in metabolism.
Journal
Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170
Informations de publication
Date de publication:
07 09 2021
07 09 2021
Historique:
received:
06
05
2021
revised:
07
07
2021
accepted:
11
08
2021
entrez:
8
9
2021
pubmed:
9
9
2021
medline:
8
4
2022
Statut:
ppublish
Résumé
Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future.
Identifiants
pubmed: 34496230
pii: S1550-4131(21)00369-7
doi: 10.1016/j.cmet.2021.08.006
pmc: PMC8428804
mid: NIHMS1735949
pii:
doi:
Substances chimiques
MicroRNAs
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1744-1762Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK063491
Pays : United States
Organisme : NIDDK NIH HHS
ID : R00 DK115998
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK101395
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK125560
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of interests The authors declare no competing interests.
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