Comparative vulnerability of PET radioligands to partial inhibition of P-glycoprotein at the blood-brain barrier: A criterion of choice?
ATP Binding Cassette Transporter, Subfamily B
/ metabolism
Animals
Biological Transport
/ drug effects
Blood-Brain Barrier
/ diagnostic imaging
Carbon Radioisotopes
/ pharmacology
Dogs
Humans
Madin Darby Canine Kidney Cells
Male
Positron-Emission Tomography
Radiopharmaceuticals
/ pharmacology
Rats
Rats, Sprague-Dawley
ATP-binding cassette
drug-drug interaction
membrane transporter
neuropharmacology
pharmacokinetics
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
01 2022
01 2022
Historique:
pubmed:
10
9
2021
medline:
9
2
2022
entrez:
9
9
2021
Statut:
ppublish
Résumé
Only partial deficiency/inhibition of P-glycoprotein (P-gp, ABCB1) function at the blood-brain barrier (BBB) is likely to occur in pathophysiological situations or drug-drug interactions. This raises questions regarding the sensitivity of available PET imaging probes to detect moderate changes in P-gp function at the living BBB.
Identifiants
pubmed: 34496661
doi: 10.1177/0271678X211045444
pmc: PMC8721783
doi:
Substances chimiques
ATP Binding Cassette Transporter, Subfamily B
0
Carbon Radioisotopes
0
Radiopharmaceuticals
0
multidrug resistance protein 3
9EI49ZU76O
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
175-185Références
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