Scanning mutagenesis of RNA-binding protein ProQ reveals a quality control role for the Lon protease.
Hfq
Lon protease
ProQ
RNA-binding proteins
protein stability
Journal
RNA (New York, N.Y.)
ISSN: 1469-9001
Titre abrégé: RNA
Pays: United States
ID NLM: 9509184
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
17
08
2021
accepted:
24
08
2021
pubmed:
10
9
2021
medline:
15
12
2021
entrez:
9
9
2021
Statut:
ppublish
Résumé
The FinO-domain protein ProQ belongs to a widespread family of RNA-binding proteins (RBPs) involved in gene regulation in bacterial chromosomes and mobile elements. While the cellular RNA targets of ProQ have been established in diverse bacteria, the functionally crucial ProQ residues remain to be identified under physiological conditions. Following our discovery that ProQ deficiency alleviates growth suppression of
Identifiants
pubmed: 34497069
pii: rna.078954.121
doi: 10.1261/rna.078954.121
pmc: PMC8594473
doi:
Substances chimiques
Bacterial Proteins
0
RNA, Bacterial
0
RNA-Binding Proteins
0
Protease La
EC 3.4.21.53
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1512-1527Informations de copyright
© 2021 El Mouali et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.
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