CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis.

Adult Biomarkers / cerebrospinal fluid Chitinases / cerebrospinal fluid Disease Progression Female Follow-Up Studies Humans Male Middle Aged Multiple Sclerosis, Chronic Progressive / cerebrospinal fluid Patient Acuity Prognosis

Journal

Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388

Informations de publication

Date de publication:
11 2021
Historique:
received: 26 02 2021
accepted: 15 07 2021
entrez: 9 9 2021
pubmed: 10 9 2021
medline: 5 2 2022
Statut: epublish

Résumé

This study aimed to identify long-term prognostic protein biomarkers associated with disease progression in patients with progressive multiple sclerosis (MS). CSF samples were collected from a discovery cohort of 28 patients with progressive MS who participated in a clinical trial with interferon beta. Patients were classified into high and low disability progression phenotypes according to numeric progression rates (NPR) and step-based progression rates (SPR) after a mean follow-up time of 12 years. Protein abundance was measured by shotgun proteomics. Selected proteins from the discovery cohort were quantified by parallel reaction monitoring in CSF samples from an independent validation cohort of 41 patients with progressive MS classified also into high and low disability progression phenotypes after a mean follow-up time of 7 years. Of 2,548 CSF proteins identified in the discovery cohort, 10 were selected for validation based on their association with long-term disability progression: SPATS2-like protein, chitinase 3-like 2 (CHI3L2), plasma serine protease inhibitor, metallothionein-3, phospholipase D4, beta-hexosaminidase, neurexophilin-1, adipocyte enhancer-binding protein 1, cathepsin L1, and lipopolysaccharide-binding protein. Only CHI3L2 was validated, and patients with high disability progression exhibited significantly higher CSF protein levels compared with patients with low disability progression ( Although further confirmatory studies are needed, we propose CSF CHI3L2 as a prognostic protein biomarker associated with long-term disability progression in patients with progressive MS. This study provides Class II evidence that high CSF CHI3L2 levels identified higher disability progression in patients with progressive MS.

Identifiants

DOI: 10.1212/NXI.0000000000001082 PMID: 34497102 PMC: PMC8428018
pubmed: 34497102
pii: 8/6/e1082
doi: 10.1212/NXI.0000000000001082
pmc: PMC8428018
pii:
doi:

Substances chimiques

Biomarkers 0
CHI3L2 protein, human EC 3.2.1.14
Chitinases EC 3.2.1.14

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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Auteurs

Manuel Comabella (M)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain. manuel.comabella@vhir.org.
ORCID: 0000-0002-2373-6657

Jaume Sastre-Garriga (J)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Eva Borras (E)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Luisa M Villar (LM)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Albert Saiz (A)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Sergio Martínez-Yélamos (S)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Juan Antonio García-Merino (JA)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Rucsanda Pinteac (R)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Nicolas Fissolo (N)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Antonio J Sánchez López (AJ)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Lucienne Costa-Frossard (L)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Yolanda Blanco (Y)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Sara Llufriu (S)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

Angela Vidal-Jordana (A)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
ORCID: 0000-0002-7270-5507

Eduard Sabidó (E)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
ORCID: 0000-0001-6506-7714

Xavier Montalban (X)

From the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Chitinase › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Sclérose en plaques chronique progressive › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › CSF Chitinase 3-Like 2 Is Associated With...
questionsmedicales.fr › Diagnostic › Pronostic › CSF Chitinase 3-Like 2 Is Associated With...