NAD
Alzheimer Disease
/ complications
Animals
Cellular Senescence
Dietary Supplements
Humans
Membrane Proteins
/ genetics
Mice
Mice, Transgenic
NAD
/ administration & dosage
Neuroinflammatory Diseases
/ drug therapy
Niacinamide
/ administration & dosage
Nucleotidyltransferases
/ genetics
Pyridinium Compounds
/ administration & dosage
Alzheimer’s disease
DNA repair
NAD supplementation
inflammation
neurodegeneration
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 09 2021
14 09 2021
Historique:
accepted:
23
07
2021
entrez:
9
9
2021
pubmed:
10
9
2021
medline:
15
12
2021
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder. Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of AD, but their interplay is not clear. Nicotinamide adenine dinucleotide (NAD
Identifiants
pubmed: 34497121
pii: 2011226118
doi: 10.1073/pnas.2011226118
pmc: PMC8449423
pii:
doi:
Substances chimiques
Membrane Proteins
0
Pyridinium Compounds
0
Sting1 protein, mouse
0
nicotinamide-beta-riboside
0I8H2M0L7N
NAD
0U46U6E8UK
Niacinamide
25X51I8RD4
Nucleotidyltransferases
EC 2.7.7.-
cGAS protein, mouse
EC 2.7.7.-
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Intramural NIH HHS
ID : Z01 AG000735
Pays : United States
Déclaration de conflit d'intérêts
Competing interest statement: V.A.B. has a Cooperative Research and Development Agreement (CRADA) with Chromadex Corporation but receives no personal benefits.
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