Coxsackievirus B Vaccines Prevent Infection-Accelerated Diabetes in NOD Mice and Have No Disease-Inducing Effect.
Journal
Diabetes
ISSN: 1939-327X
Titre abrégé: Diabetes
Pays: United States
ID NLM: 0372763
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
received:
05
03
2021
accepted:
30
08
2021
pubmed:
10
9
2021
medline:
4
1
2022
entrez:
9
9
2021
Statut:
ppublish
Résumé
Enteroviruses, including the Coxsackievirus Bs (CVB), have been implicated as causal agents in human type 1 diabetes. Immunization of at-risk individuals with a CVB vaccine provides an attractive strategy for elucidating the role of CVBs in the disease etiology. Previously, we have shown that an inactivated whole-virus vaccine covering all CVB serotypes (CVB1-6) is safe to administer and highly immunogenic in preclinical models, including nonhuman primates. Before initiating clinical trials with this type of vaccine, it was also important to address
Identifiants
pubmed: 34497136
pii: db21-0193
doi: 10.2337/db21-0193
pmc: PMC8660981
doi:
Substances chimiques
Antibodies, Neutralizing
0
Viral Vaccines
0
Banques de données
figshare
['10.2337/figshare.16556424']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2871-2878Informations de copyright
© 2021 by the American Diabetes Association.
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