Bioaccumulation of therapeutic drugs by human gut bacteria.

Animals Antidepressive Agents / metabolism Bacteria / metabolism Bioaccumulation Caenorhabditis elegans / metabolism Cells / metabolism Click Chemistry Duloxetine Hydrochloride / adverse effects Gastrointestinal Microbiome / physiology Humans Metabolomics Models, Animal Proteomics Reproducibility of Results

Journal

Nature

ISSN: 1476-4687

Titre abrégé: Nature

Pays: England

ID NLM: 0410462

Informations de publication

Date de publication:
09 2021

Historique:

received: 25 02 2019

accepted: 10 08 2021

pubmed: 10 9 2021

medline: 5 2 2022

entrez: 9 9 2021

Statut: ppublish

Résumé

Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently

Identifiants

DOI: 10.1038/s41586-021-03891-8 PMID: 34497420 PMC: PMC7614428

pubmed: 34497420

doi: 10.1038/s41586-021-03891-8

pii: 10.1038/s41586-021-03891-8

pmc: PMC7614428

mid: EMS172278

doi:

Substances chimiques

Antidepressive Agents 0

Duloxetine Hydrochloride 9044SC542W

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Pagination

533-538

Subventions

Organisme : Medical Research Council

ID : MC_UP_1605/6

Pays : United Kingdom

Organisme : Medical Research Council

ID : MC_UU_00025/11

Pays : United Kingdom

Commentaires et corrections

Type : CommentIn

Informations de copyright

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