Stress-activated kinases as therapeutic targets in pancreatic cancer.
Casein kinase 1
Mitogen-activated protein kinases
Pancreatic cancer
Small molecule inhibitor
Stress-activated protein kinases
c-Jun N-terminal kinases
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
14 Aug 2021
14 Aug 2021
Historique:
received:
28
01
2021
revised:
17
05
2021
accepted:
20
07
2021
entrez:
9
9
2021
pubmed:
10
9
2021
medline:
11
9
2021
Statut:
ppublish
Résumé
Pancreatic cancer is a dismal disease with high incidence and poor survival rates. With the aim to improve overall survival of pancreatic cancer patients, new therapeutic approaches are urgently needed. Protein kinases are key regulatory players in basically all stages of development, maintaining physiologic functions but also being involved in pathogenic processes. c-Jun N-terminal kinases (JNK) and p38 kinases, representatives of the mitogen-activated protein kinases, as well as the casein kinase 1 (CK1) family of protein kinases are important mediators of adequate response to cellular stress following inflammatory and metabolic stressors, DNA damage, and others. In their physiologic roles, they are responsible for the regulation of cell cycle progression, cell proliferation and differentiation, and apoptosis. Dysregulation of the underlying pathways consequently has been identified in various cancer types, including pancreatic cancer. Pharmacological targeting of those pathways has been the field of interest for several years. While success in earlier studies was limited due to lacking specificity and off-target effects, more recent improvements in small molecule inhibitor design against stress-activated protein kinases and their use in combination therapies have shown promising
Identifiants
pubmed: 34497429
doi: 10.3748/wjg.v27.i30.4963
pmc: PMC8384741
doi:
Substances chimiques
JNK Mitogen-Activated Protein Kinases
EC 2.7.11.24
Mitogen-Activated Protein Kinases
EC 2.7.11.24
p38 Mitogen-Activated Protein Kinases
EC 2.7.11.24
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
4963-4984Informations de copyright
©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict-of-interest statement: The authors declare no conflict of interests for this article.
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