Motilin Comparative Study: Structure, Distribution, Receptors, and Gastrointestinal Motility.
comparative biology
enteric nerves
gastrointestinal contractility
motilin
motilin receptor
smooth muscle
vagus afferent nerves
Journal
Frontiers in endocrinology
ISSN: 1664-2392
Titre abrégé: Front Endocrinol (Lausanne)
Pays: Switzerland
ID NLM: 101555782
Informations de publication
Date de publication:
2021
2021
Historique:
received:
27
04
2021
accepted:
16
07
2021
entrez:
9
9
2021
pubmed:
10
9
2021
medline:
12
2
2022
Statut:
epublish
Résumé
Motilin, produced in endocrine cells in the mucosa of the upper intestine, is an important regulator of gastrointestinal (GI) motility and mediates the phase III of interdigestive migrating motor complex (MMC) in the stomach of humans, dogs and house musk shrews through the specific motilin receptor (MLN-R). Motilin-induced MMC contributes to the maintenance of normal GI functions and transmits a hunger signal from the stomach to the brain. Motilin has been identified in various mammals, but the physiological roles of motilin in regulating GI motility in these mammals are well not understood due to inconsistencies between studies conducted on different species using a range of experimental conditions. Motilin orthologs have been identified in non-mammalian vertebrates, and the sequence of avian motilin is relatively close to that of mammals, but reptile, amphibian and fish motilins show distinctive different sequences. The MLN-R has also been identified in mammals and non-mammalian vertebrates, and can be divided into two main groups: mammal/bird/reptile/amphibian clade and fish clade. Almost 50 years have passed since discovery of motilin, here we reviewed the structure, distribution, receptor and the GI motility regulatory function of motilin in vertebrates from fish to mammals.
Identifiants
pubmed: 34497583
doi: 10.3389/fendo.2021.700884
pmc: PMC8419268
doi:
Substances chimiques
Receptors, Gastrointestinal Hormone
0
Receptors, Neuropeptide
0
motilin receptor
0
Motilin
52906-92-0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
700884Informations de copyright
Copyright © 2021 Kitazawa and Kaiya.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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